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|Title: ||The epidemiology of cervictis in sexually transmitted infection clinic populations in Sydney, Australia|
|Authors: ||Lusk, Margaret Josephine|
|Issue Date: ||29-Aug-2014|
|Publisher: ||University of Sydney|
School of Public Health
|Abstract: ||Infectious and non-infectious associations of cervicitis were explored in a prospective cross-sectional study of 550 women at three STI services in Sydney, 2006 to 2010. Associations were compared using three cervicitis case definitions: >30 polymorphonuclear leucocytes/high powered field of cervical Gram stain, yellow discharge or mucopurulent discharge (MCP). Women underwent testing for multiple infections. A prospective observational sub-study assessed the effect of Azithromycin treatment of all cervicitis and non-specific cervicitis (NSC) (cervicitis in the absence of Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG) Mycoplasma genitalium (MG), Trichomonas vaginalis (TV))
CT, MG and TV were significantly associated with increased cervicitis risk on multivariate analysis, strongest associations with MCP: CT adjusted Relative Risk (ARR) =2.61 (95% CI 1.57-4.35) p=0.0002, MG ARR =2.25 (95% CI 1.12-4.54) p=0.003, TV ARR=2.86 (95% CI 1.61-5.09) p=0.0003. NG increased cervicitis risk on univariate analysis (RR=3.66 (95% CI 2.02-6.62) p<0.0001). Condom use reduced cervicitis risk by the yellow discharge definition (ARR=0.68 (95% CI 0.50-0.92) p=0.013).
Population Attributable Risk% of significant pathogens explained only 23.4% of cervicitis and were: CT 8.5%, NG 3.6%, MG 4.5%, TV 6.7%.
Azithromycin treatment showed non-significant reductions in cervicitis persistence for all cervicitis, RR=0.74 (95% CI 0.46-1.21) p=0.235 and NSC, RR=0.60 (95% CI 0.35-1.02) P=0.058|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
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|LUSK Josephine - Final Thesis.pdf||Thesis||1.99 MB||Adobe PDF|
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