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|dc.description.abstract||Patterned polymer surfaces are of great importance with respect to an increasing number of technological and bio-medical applications, due to their great versatility in terms of chemical composition, properties and processing techniques. Surface micro-patterning by spontaneous dewetting of thin polymer films represents a versatile and robust process to fabricate surfaces with controlled topography and chemistry at the micro-scale. In this Thesis, we used polymer dewetting in combination with complementary approaches to engineer both surface chemistry and the ordering of the dewetting patterns.
The dewetting of poly(D,L-glycolide-co-lactide) (PLGA) thin films on polystyrene (PS) was combined with the grafting of protein-repellent poly(ethylene glycol) (PEG), in order to form topographical and chemical surface micropatterns consisting in protein-adhesive PS domains surrounded by protein-repellent PEG-grafted PLGA films. The produced micropatterned surfaces were used for site-specific protein adsorption, and represent a promising platform for biological applications, such as proteomics, single-cell studies and tissue engineering.
Spatially ordered surface micropatterns were obtained by combining polymer dewetting with microcontact printing and colloidal lithography, respectively. The dewetting of thin PS films was guided within specific regions of the substrate by prestamping of the silicon substrate with self-assembled monolayers of an alkylsilane by microcontact printing. Ordered micropatterns consisting in arrays of holes with tunable size were obtained by exploiting the spontaneous dewetting of poly(4-vinyl pyridine) (P4VP) thin films on PS from the holes produced by colloidal imprinting with two-dimensional colloidal crystals assembled on the polymer bilayer.||en_AU|
|dc.publisher||University of Sydney||en_AU|
|dc.publisher||Faculty of Science||en_AU|
|dc.publisher||School of Chemistry||en_AU|
|dc.title||Functional surface micropatterns by dewetting of thin polymer films||en_AU|
|dc.type.pubtype||Doctor of Philosophy Ph.D.||en_AU|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
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|2015_Manuel_Ghezzi_Thesis.pdf||PhD Thesis||4.73 MB||Adobe PDF|
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