|Title:||Trials and Outcomes in Surgery|
|Authors:||McGee, Richard Gerard Eamonn|
|Keywords:||Evidence based surgery|
Bias; Paediatric surgery
|Publisher:||University of Sydney.|
Faculty of Medicine.
School of Public Health.
|Abstract:||Surgery, as a scientific discipline, should be supported by research. Surgeons depend on the availability and quality of an adequate evidence base to provide best possible care. Randomised trials are often considered the best form of evidence when assessing the efficacy of an intervention. Surgical research has been derided because of the paucity of randomised trials published. Many efforts have been made to combat this crisis of credibility, including the creation of the IDEAL Collaboration, which aims to improve “the quality of research in surgery by emphasizing appropriate methods, transparency of data and rigorous reporting of outcomes”. This has occurred within the wider context of a drive to improve research standards across the medical research community, with notable examples being the EQUATOR Network, the COMET group, the STaR child health group, the Cochrane Collaboration, the James Lind Alliance and AllTrials initiative. These groups have made strong efforts to improve the design, conduct and reporting of clinical trials. These efforts aimed at improving research standards are likely to influence the surgical literature in a positive way. This thesis is presented as a thesis by publication: containing published and submitted work on the theme of trials and outcomes in surgery. The work presented in the first chapters of this thesis has striven to identify, evaluate and quantify the need for surgical research. The next chapters evaluate research methodology and standards in the surgical literature with a focus on paediatric surgery. The thesis concludes with an evaluation of the impact of research standards within a regulatory framework, from the perspective of medical devices. The overarching purpose of these studies was to promote the underlying theme of the thesis: to inform and improve research standards and outcomes within the field of surgery.|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|McGEE Richard - Final Thesis.pdf||Final Thesis||4.78 MB||Adobe PDF|
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