|Title:||Subclinical Cardiac Dysfunction and Hypercoagulability in survivors of Pulmonary Embolism and in patients with Schizophrenia|
|Authors:||Chow, Vincent Yin|
|Publisher:||University of Sydney.|
Faculty of Medicine.
Concord Clinical School.
|Abstract:||Pulmonary embolism (PE) and schizophrenia are common and life threatening conditions with long-term mortality due to cardiovascular and non-cardiovascular causes. In both conditions, the predictors of long-term dysfunction or mortality are poorly studied but both are suspected to have subclinical cardiac dysfunction which has not been defined. The increased risk of thrombosis recurrence in patients with PE, and thrombosis incidence in patients with schizophrenia indicates a shared predisposition to thrombosis in these conditions. This thesis examined cardiac function and global coagulation in: 1)long-term survivors of acute PE and 2)patients with schizophrenia receiving long-term antipsychotic medications including clozapine. Subclinical cardiac dysfunction and global hypercoagulability are common and under-recognised in long-term survivors of PE and in patients with schizophrenia receiving clozapine treatment. In the case of acute PE, we found that the incidence of functional impairment and RV dysfunction is much greater than suspected. Utilising the OHP (Overall Haemostatic Potential) global coagulation assay, we showed a persistent hypercoagulable state amongst long-term survivors of PE. In patients with schizophrenia receiving clozapine treatment, the incidence of subclinical LV cardiomyopathy is much more common than previously recognised. This knowledge will permit easier clinical distinction between mild asymptomatic dysfunction and serious clozapine-induced myocarditis and cardiomyopathy.|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|CHOW Vincent - Final Thesis.pdf||Thesis||5.39 MB||Adobe PDF|