|Title:||Evidence for cardiovascular autonomic dysfunction in foetal programming of hypertension following a maternal high fat or high sucrose diet|
|Authors:||Dissanayake, Hasthi Udyangani Wanamali|
|Publisher:||University of Sydney.|
School of Medical Sciences.
Discipline of Biomedical Science.
|Abstract:||Studies support the hypothesis that a maternal high fat (HFD) or high sucrose (HSU) diet during pregnancy is associated with hypertension in offspring due to mechanisms of fetal programming. In this study we tested the programming effect of a HFD and HSU diet on cardiovascular and autonomic responses at rest and in response to dehydration (DS) and air jet (AJ) stress. Pregnant rat dams were placed on a HFD (59% fat), HSU (10%w/v) or control (5% fat) diet. At 6 months the offspring were implanted with telemetry blood pressure transmitters. BP and derived spontaneous baroreflex sensitivity, heart rate variability and BP variability were measured at rest, during DS and during AJ. Offspring from a maternal HF diet show elevated BP at rest compared to controls. In response to AJ and DS, all animals showed an increase in cardiovascular variables, however, the magnitude of increase in cardiovascular variables were similar between groups in both male and female rats. We found limited evidence of altered autonomic function in the HFD rats, despite their higher blood pressure. Offspring from a maternal HSU diet showed no differences in cardiovascular or autonomic responses at rest or in response to either DS or AJ.|
|Type of Work:||Masters Thesis|
|Type of Publication:||Master of Philosophy M.Phil|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
|DISSANAYAKE Hasthi - Final thesis.pdf||Thesis||22.1 MB||Adobe PDF|
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