|Title:||Pathology in Language‐Associated Regions of Primary Progressive Aphasia|
|Publisher:||University of Sydney.|
Discipline of Pathology
School of Medical Sciences.
|Abstract:||Primary progressive aphasia (PPA) is a neurodegenerative disorder causing prominent language impairment. There are three subtypes: the semantic variant (sv-PPA), non-fluent variant (nfv- PPA), and logopenic variant (lv- PPA). This study sought to examine whether these variants can be differentiated on the basis of cellular changes, as well as the severity of underlying AD pathology. Cortical blocks from BA40, 22, 38, 44/45 from 8 sv-PPA and 7 nfv- PPA, lv-PPA and control subjects were obtained from the Cambridge and Sydney Brain Banks. Neuronal cell counts were performed on cresyl violet stained sections, and AD pathology assessed on silver stained sections. Significant neuronal loss and atrophy was observed in BA38 of the sv-PPA group. sv-PPA subjects also had the lowest severity of AD pathology, which distinguished this variant. The nfv-PPA and lv-PPA had a similar reduction in neuronal density in BA40/22. However, correlation analysis showed lv-PPA lost neurons early in the disease course compared to nfv-PPA. The lv-PPA group was characterised by the most prominent atrophy and neuronal loss in BA40/22, and the greatest neuronal damage due to AD pathology. These results show it is possible to distinguish the variants on the basis of cellular changes in these regions. In addition, the results show lv-PPA has the highest propensity for underlying AD pathology out of the PPA variants, which could influence development of future therapies.|
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|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||Masters Thesis|
|Type of Publication:||Master of Philosophy M.Phil|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|BRITTON Anna - Final Thesis.pdf||Thesis||18.32 MB||Adobe PDF|
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