|Title:||The Impact of Perinatal and Infant Nutrition on Childhood health and Academic Outcomes|
|Publisher:||University of Sydney.|
Woolcock Institute of Medical Research.
Central Clinical School - RPAH
|Abstract:||This thesis contributes to the field of life course epidemiology by focusing on the relation of breastfeeding, birth weight and omega-3 fatty acid supplementation to respiratory, sleep and cognitive outcomes. This research consisted of five major components including: a systematic review and meta-analysis of studies investigating the association between breastfeeding and wheezing illness in children over 5 years of age; a meta-regression combining the data of two cohorts, from Australia and Sweden that had previously found different associations between breastfeeding, asthma and allergy; a prospective cohort study investigating the association between perinatal anthropometric factors, lung function and asthma at age 8 years; a prospective cohort study investigating breastfeeding and its association with sleep disordered breathing outcomes at age 8; and, a randomised controlled trial testing the effect of omega-3 fatty acid supplementation in the first 5 years of life on academic performance. Taken together, these studies support the view that early life nutrition has long term effects on health outcomes in children particularly regarding wheeze, asthma, lung function, snoring and food allergies. Omega-3 fatty acid supplementation for cognitive benefits is not supported. Even after attempting to reduce heterogeneity between breastfeeding and asthma studies using a meta-regression and meta-analysis, differences remained. It is recommended that future breastfeeding studies attempt to control for confounding factors unique to each setting, such as socioeconomic status.|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|BREW Bronwyn - Final Thesis.pdf||5.52 MB||Adobe PDF|
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