|Title:||Inhibition of biofilm formation on polymer medical devices|
|Authors:||Loo, Judy Ching-Yee|
|Publisher:||University of Sydney.|
Faculty of Pharmacy.
|Abstract:||Endotracheal intubation is commonly associated with hospital-acquired infections as the plastic tubes act as a reservoir for bacterial colonization in lungs, which subsequently develops into life-threatening biofilms. Therefore, the main aim of this Thesis was to evaluate possible strategies to i) delay or prevent the colonization microorganism; and ii) eradicate and kill mature biofilms by engineering a series of novel coatings that can be incorporated into endotracheal tubes. In this study two different approaches have been used which include surface modification of a medical plastic and the utilization of silver nanoparticles (AgNPs) as anti-biofilm agents in either mono-drug or combination-drug therapy approaches. Additionally, curcumin nanoparticles (Cur-NP) were investigated in combination with AgNPs for enhanced anti-biofilm activity. The microorganism used in the Thesis were a Gram-negative clinical isolate strain Pseudomonas aeruginosa PAO1 and a Gram-positive Staphylococcus aureus as these bacteria are the main pathogens associated with endotracheal infections and biofilm occurrences in ventilated patients.|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|LOO Ching Yee Judy - Final Thesis.pdf||8.16 MB||Adobe PDF|
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