|Title:||Inhaled rifamycin dry powders targeting tuberculosis|
|Authors:||Chan, John Gar Yan|
|Publisher:||University of Sydney.|
School of Medical Sciences.
Discipline of Pharmacology.
|Abstract:||A third of the world population have tuberculosis, a bacterial infection spread and contracted primarily by the respiratory route. Although an effective treatment in the form of oral antibiotics is available, treatment times of at least six months continue to hinder efforts to rapidly eradicate the disease. This thesis investigates delivery of the rifamycin class of drugs directly to the pulmonary site of infection by inhalation, which might realise considerably faster treatment of the disease when used in conjunction with oral therapy. Following extensive development and characterisation studies, an inhalable triple and single antibiotic dry powder were successfully produced and are now undergoing further in vivo investigation. These inhalable dry powders could have significant implications for anti-tubercular therapy and the way novel anti-tubercular drugs will be administered to patients.|
|Description:||Includes published papers co-authored with others|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|CHAN John Gar Yan - Final thesis.pdf||Thesis||6.6 MB||Adobe PDF|
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