|Title:||Arousal, Sleep and Cardiovascular Responses to Intermittent Hypercapnic Hypoxia in Piglets|
|Keywords:||Sleep apnea syndromes.|
Hypercapnia -- Pathophysiology.
Anoxemia -- Physiological effect
|Publisher:||University of Sydney.|
Faculty of Medicine
|Abstract:||Clinical studies have demonstrated an arousal deficit in infants suffering Obstructive Sleep Apnoea (OSA), and that treatment to alleviate the symptoms of OSA appears to reverse the deficit in arousability. Some sudden infant deaths are thought to be contingent upon such an arousal deficit. This research utilised young piglets during early postnatal development, and exposed them to intermittent hypercapnic hypoxia (IHH) as a model of clinical respiratory diseases. Arousal responses of control animals were compared to the animals exposed to IHH. Comparisons were also made between successive exposures on the first and the fourth consecutive days of IHH. Time to arouse after the onset of the respiratory stimulus, and frequency of arousals during recovery, demonstrated that arousal deficits arose after successive exposures and that these were further exacerbated on the fourth study day. After an overnight recovery period, the arousal deficit was apparently dormant, and only triggered by HH exposure. These studies confirm that both acute and chronic deficits can be induced on a background of otherwise normal postnatal development, suggesting that deficits observed in the clinical setting may be a secondary phenomenon.|
|Description:||Master of Science (Medicine)|
|Rights and Permissions:||The author retains copyright of this thesis.|
|Type of Work:||Masters Thesis|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
|01front.pdf||163.93 kB||Adobe PDF|
|02whole.pdf||3.12 MB||Adobe PDF|
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