|Title:||Improving and Implementing Diagnostic Tools in Pathology with a Focus on Haemostasis and Association with Select Endocrine Disorders|
|Authors:||Mina, Ashraf Anis Wahba|
|Publisher:||University of Sydney.|
Sydney Medical School.
Western Clinical School.
|Abstract:||The literature and evidence base associating haemostatic dysfunction associated with some of endocrine disorders as major risk factors and causes of human morbidity and mortality was reviewed and published. A detailed protocol to define and develop instrument selection and evaluation and implementation in pathology and research, also its impact on method development and objective evaluation was developed and published. A new quality control model using performance goals based on biological variation in External Quality Assurance Schemes was developed and published. A robust and cost effective method for estimating iodine as indicator of thyroid abnormality which can be used to identify patients with thyroid disorders that are prone to risk of bleeding and/or thrombosis was developed and published. A novel functional assay to estimate Von Willbrand factor (VWF)/antigen and collagen binding was developed and published. Evaluation of short activated partial thromboplastin times (APTT), as potential representation of a complex hypercoagulant milieu that could feasibly contribute to thrombotic risk, was assessed and published. Assessment of the relationship between short APTTs, thrombin generation, procoagulant factors [fibrinogen and Factors (V, VIII, IX, XI and XII)], VWF, and procoagulant phospholipid activity was also achieved and published. A study designed to investigate select haemostasis, endocrine and biochemical parameters in women who undergo in-vitro fertilisation, before and after stimulation with follicle stimulating hormone was achieved and submitted for publication.|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|MINA Ashraf - Final Thesis.pdf||PhD Thesis||2.3 MB||Adobe PDF|
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