|Title:||Timecourse of Cognitive and Brain Adaptation to Cognitive Training in At-risk Elderly|
|Publisher:||University of Sydney.|
Faculty of Medicine.
Brain and Mind Research Institute.
|Abstract:||Maintaining cognitive ability in the elderly is a global priority. Computerised cognitive training (CCT) is among the few effective interventions but the boundaries and mechanisms underlying its effectiveness are largely unknown. Chapter 2 is the first systematic review and meta-analysis of 37 randomised controlled trials (RCTs) of CCT in healthy elderly, encompassing a total of 4,310 participants. CCT was effective on all the cognitive domains except for executive functions. Type of training program, mode of delivery, session length and training frequency were found to moderate CCT efficacy. The Timecourse Trial (Chapter 3) was a randomized, double-blind, active controlled longitudinal trial of CCT in 80 healthy elderly. Significant effects were found on global cognition, memory and processing speed, and dose-response curves differed across domains. These domain-specific gains also followed different decay curves after training cessation throughout the 12 months follow-up period. Chapter 4 investigates the neural underpinnings of gains in global cognition. Modification of resting-state functional connectivity was found to predict subsequent cognitive gains, gains that were also correlated to structural cortical plasticity. CCT is an effective intervention in the elderly. The field may do well to now focus on improving standards, large-scale trials and a further understanding of biological mechanisms.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
|LAMPIT Amit - Final Thesis.pdf||Final thesis||15.33 MB||Adobe PDF|
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