|Title:||Outcomes of Kidney Transplantation|
|Publisher:||University of Sydney.|
Faculty of Medicine.
Central Clinical School.
|Abstract:||Kidney transplantation is the preferred treatment for the majority of patients with end-stage kidney disease, offering improved survival and quality of life compared with dialysis at reduced cost. However, kidney transplantation remains a treatment rather than a cure. A good outcome requires appropriate donor and recipient selection, careful management of immunosuppression, and avoidance of long-term complications including death from cardiovascular disease or malignancy, and graft loss from chronic allograft nephropathy or recurrence of the primary kidney disease. Making use of data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, supplemented where necessary by other sources, this thesis contains a number of linked epidemiologic investigations: (1) a report of the risk profile of Australian and New Zealand living kidney donors over 2004-11; (2) simulations of the allocation of deceased donor kidneys in Australia over 2006-2010, and development of novel metrics for the utility and equity of each allocation system; (3) external validation of the US estimated post-transplant survival (EPTS) score; (4) study of the long-term consequences of early acute rejection; (5) 15 year follow-up of a randomised trial of mycophenolate vs azathioprine; and (6) analysis of the association between steroid use and graft loss from recurrent IgA nephropathy.|
|Access Level:||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions:||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work:||PhD Doctorate|
|Type of Publication:||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
|CLAYTON Phillip - Final thesis.pdf||Final Thesis||11.65 MB||Adobe PDF|
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