Show simple item record

FieldValueLanguage
dc.contributor.authorKaur, Manreena
dc.date.accessioned2014-03-03
dc.date.available2014-03-03
dc.date.issued2013-07-18
dc.identifier.urihttp://hdl.handle.net/2123/10104
dc.description.abstractThis thesis investigated two established neurophysiological biomarkers of schizophrenia: mismatch negativity (MMN) and P3a; purported indices of the deviance detection and orienting response, respectively. In light of recent interest into a shared diathesis model between schizophrenia- and affective-spectrum disorders, this thesis evaluated the utility of MMN/P3a in informing the underlying neurobiology of early stages of schizophrenia- and affective-spectrum disorders. Despite differences in the composition of schizophrenia- and affective-spectrum subgroups, the first two studies showed that MMN/P3a was similarly impaired in the two diagnostic spectrums, with the schizophrenia-spectrum displaying more severe/widespread impairments. The third study utilised a data-driven method and determined three clusters with distinct patterns of MMN/P3a amplitudes among patients with emerging schizophrenia- and affective-spectrum disorders. Critically, about half of the cluster with the greatest neurophysiological impairments consisted of schizophrenia-spectrum patients. The last study explored the stability of MMN/P3a over time and its value in predicting functional outcomes in schizophrenia- and affective-spectrum patients. This study showed that MMN impairments worsen over time, suggestive of ongoing pathophysiological processes. Additionally, greater deficits in MMN amplitudes at baseline were associated with the most severe levels of later disability. In conclusion, this work has been a substantial contribution to the somewhat limited literature on MMN and P3a in early psychotic (and related) disorders. Critically, this thesis supports a re-conceptualisation of the proposed neurophysiological biomarkers of schizophrenia by demonstrating a broader application of MMN and P3a (in early schizophrenia- and affective-spectrum disorders). Accordingly, these studies also provide neurophysiological evidence of a shared diathesis between schizophrenia- and bipolar-spectrum disorders.en_AU
dc.publisherUniversity of Sydney
dc.publisherFaculty of Medicine
dc.publisherBrain and Mind Research Institute
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.subjectmismatch negativityen_AU
dc.subjectP3aen_AU
dc.subjectschizophrenia-spectrumen_AU
dc.subjectaffective-spectrumen_AU
dc.subjectyouth mental healthen_AU
dc.subject.otherincludes published articlesen_AU
dc.titleReconceptualising neurophysiological biomarkers of schizophrenia: an investigation of the MMN/P3a complex in early stage psychiatric disordersen_AU
dc.typePhD Doctorateen_AU
dc.type.pubtypeDoctor of Philosophy Ph.D.en_AU
dc.description.disclaimerAccess is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.en_AU


Show simple item record

Associated file/s

Associated collections

Show simple item record

There are no previous versions of the item available.