Browsing by author "Todd, Matthew H"
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ARC Open Access Policy Info Session
Holcombe, Alex; Todd, Matthew H; Arndell, Michael; Christensen, Sten; Stanton, KatePublished 2013-01-25Presentations from the ARC Open Access Policy Info Session for the Faculty of Science at the University of SydneyOpen AccessPresentation -
Electronic Lab Notebook for Synthesis of Tuberculosis Drug Leads
Badiola, Katrina; Todd, Matthew HPublished 2013-01-01A snapshot of an electronic laboratory notebook used to record the synthesis of new small molecules intended for the treatment of tuberculosis. The compounds are synthesised using an oxa-Pictet Spengler reaction, and are ...Open AccessDataset -
Electronic Laboratory Notebook Snapshots for paper entitled Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
Todd, Matthew HPublished 2015-01-01The files are zipped snapshots of the electronic laboratory notebooks (ELNs) used by the Open Source Malaria (OSM) consortium that are relevant to the paper "Open Source Drug Discovery - Highly Potent Antimalarial Compounds ...Open AccessOther -
Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands
Lau, Yu Heng; Clegg, Jack K; Price, Jason R; Macquart, Rene B; Todd, Matthew H; Rutledge, Peter JPublished 2017-10-19Molecular switches have many potential applications in nanoscience and biomedicine. Transition metal complexes that can be switched from an inert, unreactive state to a catalytically active one by a simple change in ...Open AccessArticle, Letter -
NMR Data for Synthesis of Spiro Tuberculosis Drug Leads
Badiola, Katrina; Todd, Matthew HPublished 2014-05-14NMR data supporting Electronic Lab Notebook for Synthesis of Tuberculosis Drug Leads (http://hdl.handle.net/2123/10461), specifically the paper published based on this work. The NMR spectra/data are for the chemical compounds ...Open AccessDataset -
Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
Yu, Mingfeng; Nagalingam, Gayathri; Ellis, Samantha; Martinez, Elena; Sintchenko, Vitali; Spain, Malcolm; Rutledge, Peter J; Todd, Matthew H; Triccas, James A.Published 2016-05-23Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...Open AccessArticle -
Open Source Malaria Consultation
Todd, Matthew HPublished 2012-08-20Open online consultation of the Open Source Malaria Consortium. A discussion on the Consortium's Series 1, including decisions on which compounds next to target with chemical synthesis. Relevant structures may be found in ...Open AccessAudiovisual -
Open Source Malaria Wiki. Archived Snapshots of Series 1 and 4.
Todd, Matthew H; Williamson, Alice E; Lee, Jessica S; Ylioja, Paul MPublished 2016-01-01Archived snapshots of wiki pages for Open Source Malaria from July 2016. Uploaded in part as supporting information in parallel to a journal submission describing the work in full.Open AccessPre-print -
Selective displacement of a scorpionand triazole ligand from metallocyclam complexes visualised using NMR spectroscopy.
Wong, Joseph; Proschogo, Nicholas; Todd, Matthew H; Rutledge, Peter JPublished 2017-01-15Target-activated metal complexes (TAMCs) – complexes that remain benign until reaching a specific biomolecular target, binding to which then affects structural change that turns on cytotoxicity or other activity – hold ...Open AccessArticle -
Supporting Information - NMR Spectra for Novel Compounds for Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
Todd, Matthew H; Williamson, AlicePublished 2015-12-08NMR spectra for novel compounds associated with submission of paper entitled "Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles".Open AccessOther -
Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions
Ast, Sandra; Kuke, Stefanie; Rutledge, Peter J; Todd, Matthew HPublished 2014-12-05Four cyclam-based fluorescent molecular probes were prepared using ‘click’ chemistry and investigated to determine the effect of the triazole connectivity and fluorophore substitution on photophysical properties and metal ...Open AccessArticle
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