Browsing by author "Simes, R John"
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The cost effectiveness of bevacizumab when added to capecitabine, with or without mitomycin-C, in first line treatment of metastatic colorectal cancer: results from the Australasian phase III MAX study
Carter, Hannah; Zannino, Diana; Simes, R John; Schofield, Deborah J; Howard, Kirsten; Zalcberg, John R; Price, Timothy J; Tebbutt, Niall CPublished 2015-12-14Background: Based on the clinical data, bevacizumab has been approved in Australia and globally for the treatment of advanced colorectal cancer. However, limited evidence exists for its cost-effectiveness. The purpose of ...Open AccessArticle -
Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
Davis, Timothy ME; Ting, Ru-Dee; Best, James D; Donoghoe, Mark; Drury, Paul L; Sullivan, David R; Jenkins, Alicia J; O'Connell, Rachel L; Whiting, Malcolm; Glasziou, Paul; Simes, R John; Kesaniemi, Y Antero; Gebski, Val; Scott, Russell; Keech, Anthony CPublished 2011-02-01Abstract Aims/hypothesis Fenofibrate caused an acute, sustained plasma creatinine increase in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and Action to Control Cardiovascular Risk in Diabetes ...Open AccessPost-print -
Hope, optimism and survival in a randomized trial of chemotherapy for metastatic colorectal cancer
Schofield, PE; Stockler, MR; Zannino, D; Tebbutt, NC; Price, TJ; Simes, R John; Wong, N; Pavlakis, N; Ransom, D; Moylan, E; Underhill, C; Wyld, D; Burns, i; Ward, R; Wilcken, N; Jefford, MPublished 2015-06-21Purpose: Psychological responses to cancer are widely believed to affect survival. We investigated associations between hope, optimism, anxiety, depression, health utility and survival in patients starting first line ...Open AccessArticle -
Linking the evidence: intermediate outcomes in medical test assessments
Staub, Lukas P; Dyer, Suzanne; Lord, Sarah J; Simes, R JohnPublished 2012-01-01Objectives To review how health technology assessments (HTA) of medical tests incorporate intermediate outcomes in conclusions about the effectiveness of tests on improving health outcomes. Methods Systematic review of ...Open AccessPost-print -
Quality-adjusted survival as an end point in breast cancer trials
Martin, Andrew J; Simes, R JohnPublished 2013-06-01Breast cancer treatment recommendations will often require an appraisal of likely benefits in relation to likely side-effects on survival and quality of life (QoL) endpoints, and possibly also an evaluation of the size of ...Open AccessArticle -
Sentinel-lymph-node-based management or routine axillary clearance? Three-year outcomes of the RACS Sentinel Node Biopsy versus Axillary Clearance (SNAC) 1 trial
Wetzig, Neil; Gill, Peter Grantley; Zannino, Diana; Stockler, Martin R; Gebski, Val; Ung, Owen; Campbell, Ian; Simes, R JohnPublished 2014-10-15Purpose We sought to determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) at 1 year persisted to 3 years of follow-up. Methods 1088 women with clinically node ...Open AccessArticle -
Single-agent irinotecan or FOLFIRI as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis
Clarke, Stephen; Yip, Sonia; Brown, Chris; Van Hazel, Guy; Ransom, David T; Goldstein, David; Jeffrey, G Mark; Tebbutt, Niall C; Buck, Martin; Lowenthal, Raymond M; Boland, Amy; Gebski, Val; Zalcberg, John; Simes, R JohnPublished 2011-06-10Background Second-line treatment with irinotecan for advanced or metastatic colorectal cancer prolongs survival. It is uncertain whether irinotecan is better administered with 5- fluorouracil or alone in patients previously ...Open AccessArticle -
Trade-offs in quality of life and survival with chemotherapy for advanced breast cancer: mature results of a randomized trial comparing single-agent mitoxantrone with combination cyclophosphamide, methotrexate, 5-fluorouracil and prednisone
Lee, Chee Khoon; Gebski, Val G; Coates, Alan S; Veillard, Anne-Sophie; Harvey, Vernon; Tattersall, Martin HN; Byrne, Michael; Byrne, Michael J; Brigham, Brian; Forbes, John; Simes, R JohnPublished 2013-08-21Background: We evaluate trade-offs between quality of life (QoL) and survival improvement for two chemotherapy regimens in advanced breast cancer. We also report on the long-term survival of patients in the ANZ 8614 clinical ...Open AccessArticle -
Using patient management as a surrogate for patient health outcomes in diagnostic test evaluation
Staub, Lukas P; Lord, Sarah J; Simes, R John; Dyer, Suzanne; Houssami, Nehmat; Chen, Robert YM; Irwig, LesPublished 2012-01-01Background: Before a new test is introduced in clinical practice, evidence is needed to demonstrate that its use will lead to improvements in patient health outcomes. Studies reporting test accuracy may not be sufficient, ...Open AccessArticle
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