Browsing by author "O'Brien, R"
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The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments.
Kim, JH; Nguyen, DT; Booth, JT; Huang, CY; Fuangrod, T; Poulsen, P; O'Brien, R; Caillet, V; Eade, T; Kneebone, A; Keall, PPublished 2018-02-01BACKGROUND AND PURPOSE: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. MATERIAL ...Open AccessArticle -
The Accuracy and Precision of the KIM Motion Monitoring System Used in the Multi-Institutional TROG 15.01 Stereotactic Prostate Ablative Radiotherapy With KIM (SPARK) Trial
Hewson, E; Nguyen, DT; O'Brien, R; Kim, J-H; Montanaro, T; Moodie, T; Greer, P; Hardcastle, N; Eade, T; Kneebone, A; Hruby, G; Hayden, A; Turner, S; Siva, S; Tai, K-H; Hunter, P; Sams, J; Poulsen, P; Booth, J; Martin, J; Keall, PPublished 2019-01-01Purpose: Kilovoltage intrafraction monitoring (KIM) allows for real-time image guidance for tracking tumor motion in six-degrees-of-freedom (6DoF) on a standard linear accelerator. This study assessed the geometric accuracy ...Open AccessArticle -
The adaptation and investigation of cone-beam CT reconstruction algorithms for horizontal rotation fixed-gantry scans of rabbits.
Gardner, M; Dillon, O; Shieh, C-C; O'Brien, R; Debrot, E; Barber, J; Ahern, V; Bennett, P; Heng, SM; Corde, S; Jackson, M; Keall, PPublished 2021Fixed-gantry radiation therapy has been proposed as a low-cost alternative to the conventional rotating-gantry radiation therapy, that may help meet the rising global treatment demand. Fixed-gantry systems require gravitational ...Open AccessArticle -
Adapting to the motion of multiple independent targets using multileaf collimator tracking for locally advanced prostate cancer: Proof of principle simulation study.
Hewson, E; Ge, Y; O'Brien, R; Roderick, S; Bell, L; Poulsen, P; Eade, T; Booth, J; Keall, P; Nguyen, DTPublished 2021Purpose: For patients with locally advanced cancer, multiple targets are treated simultaneously with radiotherapy. Differential motion between targets can compromise the treatment accuracy, yet there are currently no methods ...Open AccessArticle -
An augmented correlation framework for the estimation of tumour translational and rotational motion during external beam radiotherapy treatments using intermittent monoscopic x-ray imaging and an external respiratory signal.
Nguyen, DT; Booth, JT; Caillet, V; Hardcastle, N; Briggs, A; Hadad, C; Eade, T; O'Brien, R; Keall, PPublished 2018-10-01Increasing evidence shows that intrafraction tumour motion monitoring must include both six degrees of freedom (6DoF): 3D translations and 3D rotations. Existing real-time algorithms for 6DoF target motion estimation require ...Open AccessArticle -
Both four-dimensional computed tomography and four-dimensional cone beam computed tomography under-predict lung target motion during radiotherapy.
Steiner, E; Shieh, CC; Caillet, V; Booth, J; O'Brien, R; Briggs, A; Hardcastle, N; Jayamanne, D; Szmura, K; Eade, T; Keall, PPublished 2019-06-01BACKGROUND AND PURPOSE: To test the hypothesis that 4DCT and 4DCBCT-measured target motion ranges predict target motion ranges during lung cancer SABR. MATERIALS AND METHODS: Ten lung SABR patients were implanted with ...Open AccessArticle -
Cone-beam CT reconstruction with gravity-induced motion.
Shieh, CC; Barber, J; Counter, W; Sykes, J; Bennett, P; Heng, SM; White, P; Corde, S; Jackson, M; Ahern, V; Feain, I; O'Brien, R; Keall, PPublished 2018-10-01Fixed-gantry cone-beam computed tomography (CBCT), where the imaging hardware is fixed while the subject is continuously rotated 360° in the horizontal position, has implications for building compact and affordable ...Open AccessArticle -
Development and commissioning of a full-size prototype fixed-beam radiotherapy system with horizontal patient rotation.
Liu, PZY; O'Brien, R; Heng, SM; Newall, M; Downes, S; Shieh, CC; Corde, S; Jackson, M; Keall, PPublished 2019-03-01PURPOSE: Compared to conventional linacs with rotating gantries, a fixed-beam radiotherapy system could be smaller, more robust and more cost-effective. In this work, we developed and commissioned a prototype x-ray ...Open AccessArticle -
DMLC tracking and gating can improve dose coverage for prostate VMAT
Colvill, E; Poulsen, P; Booth, J; O'Brien, R; Ng, J; Keall, PPublished 2014-09-01PURPOSE: To assess and compare the dosimetric impact of dynamic multileaf collimator (DMLC) tracking and gating as motion correction strategies to account for intrafraction motion during conventionally fractionated ...Open AccessArticle -
Dual cardiac and respiratory gated thoracic imaging via adaptive gantry velocity and projection rate modulation on a linear accelerator: A Proof-of-Concept Simulation Study.
Reynolds, T; Shieh, C-C; Keall, P; O'Brien, RPublished 2019-01-01Purpose: Cardiac motion is typically not accounted for during pretreatment imaging for central lung and mediastinal tumors. However, cardiac induced tumor motion averages 5.8 mm for esophageal tumors and 3-5 mm for some ...Open AccessArticle -
Electromagnetic-Guided MLC Tracking Radiation Therapy for Prostate Cancer Patients: Prospective Clinical Trial Results.
Keall, P; Colvill, E; O'Brien, R; Caillet, V; Eade, T; Kneebone, A; Hruby, G; Poulsen, PR; Zwan, B; Greer, PB; Booth, JPublished 2018-06-01PURPOSE: To report on the primary and secondary outcomes of a prospective clinical trial of electromagnetic-guided multileaf collimator (MLC) tracking radiation therapy for prostate cancer. METHODS AND MATERIALS: Twenty-eight ...Open AccessArticle -
The first clinical implementation of a real-time six degree of freedom target tracking system during radiation therapy based on Kilovoltage Intrafraction Monitoring (KIM).
Nguyen, DT; O'Brien, R; Kim, JH; Huang, CY; Wilton, L; Greer, P; Legge, K; Booth, JT; Poulsen, PR; Martin, J; Keall, PPublished 2017-04-01PURPOSE: We present the first clinical implementation of a real-time six-degree of freedom (6DoF) Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during ...Open AccessArticle -
The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator.
Keall, P; Nguyen, DT; O'Brien, R; Caillet, V; Hewson, E; Poulsen, PR; Bromley, R; Bell, L; Eade, T; Kneebone, A; Martin, J; Booth, JTPublished 2018-04-01PURPOSE: Until now, real-time image guided adaptive radiation therapy (IGART) has been the domain of dedicated cancer radiotherapy systems. The purpose of this study was to clinically implement and investigate real-time ...Open AccessArticle -
The first clinical treatment with kilovoltage intrafraction monitoring (KIM): A real-time image guidance method
Keall, P; Ng, J; O'Brien, R; Colvill, E; Huang, C-Y; Poulsen, P; Fledelius, W; Juneja, P; Simpson, E; Bell, L; Alfieri, F; Eade, T; Kneebone, A; Booth, JPublished 2015-01-01PURPOSE: Kilovoltage intrafraction monitoring (KIM) is a real-time image guidance method that uses widely available radiotherapy technology, i.e., a gantry-mounted x-ray imager. The authors report on the geometric and ...Open AccessArticle -
The First Implementation of Respiratory Triggered 4DCBCT on a Linear Accelerator
O'Brien, R; Cooper, B; Shieh, C-C; Stankovic, U; Keall, P; Sonke, J-JPublished 2016-05-01Four Dimensional Cone Beam Computed Tomography (4DCBCT) is an image guidance strategy used for patient positioning in radiotherapy. In conventional implementations of 4DCBCT, a constant gantry speed and a constant projection ...Open AccessArticle -
The first patient treatment of electromagnetic-guided real time adaptive radiotherapy using MLC tracking for lung SABR.
Booth, JT; Caillet, V; Hardcastle, N; O'Brien, R; Szymura, K; Crasta, C; Harris, B; Haddad, C; Eade, T; Keall, PPublished 2016-10-01BACKGROUND AND PURPOSE: Real time adaptive radiotherapy that enables smaller irradiated volumes may reduce pulmonary toxicity. We report on the first patient treatment of electromagnetic-guided real time adaptive radiotherapy ...Open AccessArticle -
The first prospective implementation of markerless lung target tracking in an experimental quality assurance procedure on a standard linear accelerator.
Mueller, M; Zolfaghari, R; Briggs, A; Furtado, H; Booth, J; Keall, P; Nguyen, D; O'Brien, R; Shieh, CCPublished 2020-01-01The ability to track tumour motion without implanted markers on a standard linear accelerator (linac) could enable wide access to real-time adaptive radiotherapy for cancer patients. We previously have retrospectively ...Open AccessArticle -
Geometric uncertainty analysis of MLC tracking for lung SABR.
Caillet, V; Zwan, B; Briggs, A; Hardcastle, N; Szymura, K; Prodreka, A; O'Brien, R; Harris, BE; Greer, P; Haddad, C; Jayamanne, D; Eade, T; Booth, J; Keall, PPublished 2020Purpose: The purpose of this work was to report on the geometric uncertainty for patients treated with multi-leaf collimator (MLC) tracking for lung SABR to verify the accuracy of the system. Methods: Seventeen patients ...Open AccessArticle -
Impact of audiovisual biofeedback on interfraction respiratory motion reproducibility in liver cancer stereotactic body radiotherapy.
Pollock, S; Tse, R; Martin, D; McLean, L; Pham, M; Tait, D; Estoesta, R; Whittington, G; Turley, J; Kearney, C; Cho, G; Hill, R; Pickard, S; Aston, P; Makhija, K; O'Brien, R; Keall, PPublished 2018-02-01INTRODUCTION: Irregular breathing motion exacerbates uncertainties throughout a course of radiation therapy. Breathing guidance has demonstrated to improve breathing motion consistency. This was the first clinical ...Open AccessArticle -
An interdimensional correlation framework for real-time estimation of six degree of freedom target motion using a single x-ray imager during radiotherapy.
Nguyen, DT; Bertholet, J; Kim, JH; O'Brien, R; Booth, JT; Poulsen, PR; Keall, PPublished 2017-12-01Increasing evidence suggests that intrafraction tumour motion monitoring needs to include both 3D translations and 3D rotations. Presently, methods to estimate the rotation motion require the 3D translation of the target ...Open AccessArticle
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