Browsing by author "Khandelia, Himanshu"
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Electrostatic stabilization plays a central role in autoinhibitory regulation of the Na+,K+-ATPase
Jiang, Qiucen; Garcia, Alvaro; Han, Minwoo; Cornelius, Flemming; Apell, Hans-Jurgen; Khandelia, Himanshu; Clarke, Ronald J.Published 2017-01-24The Na+,K+-ATPase is present in the plasma membrane of all animal cells. It plays a crucial role in maintaining the Na+ and K+ electrochemical potential gradients across the membrane, which are essential in numerous ...Open AccessArticle -
Evidence for ATP interaction with phosphatidylcholine bilayers
Garcia, Alvaro; Pochinda, Simon; Elgaard-Jorgensen, Paninnguaq N.; Khandelia, Himanshu; Clarke, Ronald J.Published 2019-07-10ATP is a fundamental intracellular molecule and is thought to diffuse freely throughout the cytosol. Evidence obtained from nucleoside-sensing sarcolemmal ion channels and red blood cells, however, suggest that ATP is ...Open AccessArticle -
Interaction of N-terminal peptide analogues of the Na+,K+-ATPase with membranes
Nguyen, Khoa; Garcia, Alvaro; Sani, Marc-Antoine; Diaz, Dil; Dubey, Vikas; Clayton, Daniel; Dal Poggetto, Giovanni; Cornelius, Flemming; Payne, Richard J.; Separovic, Frances; Khandelia, Himanshu; Clarke, Ronald J.Published 2018-03-06The Na+,K+-ATPase, which is present in the plasma membrane of all animal cells, plays a crucial role in maintaining the Na+ and K+ electrochemical potential gradients across the membrane. Recent studies have suggested that ...Open AccessArticle -
Membrane accessibility of glutathione
Garcia, Alvaro; Eljack, Nasma D.; Sani, Marc-Antoine; Separovic, Frances; Rasmussen, Helge H.; Kopec, Wojciech; Khandelia, Himanshu; Cornelius, Flemming; Clarke, Ronald J.Published 2015-07-30Regulation of the ion pumping activity of the Na+,K+-ATPase is crucial to the survival of animal cells. Recent evidence has suggested that the activity of the enzyme could be controlled by glutathionylation of cysteine ...Open AccessArticle
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