Browsing by author "Keech, Anthony C"
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Association of Contemporary Sensitive Troponin I Levels at Baseline and Change at 1 Year With Long-Term Coronary Events Following Myocardial Infarction or Unstable Angina : Results From the LIPID Study (Long-Term Intervention With Pravastatin in Ischaemic Disease)
White, Harvey D; Tonkin, Andrew; Simes, John; Mann, Kristy; Thompson, Peter; Colquhoun, David; West, Malcolm; Nestel, Paul; Sullivan, David; Keech, Anthony C; Hunt, David; Blankenberg, StefanPublished 2013-09-30Objectives This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects ...Open AccessArticle -
Changes in Lipoprotein-Associated Phospholipase A2 Activity Predict Coronary Events and Partly Account for the Treatment Effect of Pravastatin: Results From the Long-term Intervention with Pravastatin in Ischemic Disease Study
White, Harvey D; Simes, John; Stewart, Ralph AH; Blankenberg, Stefan; Barnes, Elizabeth H; Marschner, Ian C; Thompson, Peter; West, Malcolm; Zeller, Tanja; Colquhoun, David M; Nestel, Paul; Keech, Anthony C; Sullivan, David R; Hunt, David; Tonkin, AndrewPublished 2013-10-01Background-—Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with coronary heart disease (CHD) in healthy individuals and in patients who have had ischemic events. Methods and Results-—The Long-term ...Open AccessArticle -
Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
Davis, Timothy ME; Ting, Ru-Dee; Best, James D; Donoghoe, Mark; Drury, Paul L; Sullivan, David R; Jenkins, Alicia J; O'Connell, Rachel L; Whiting, Malcolm; Glasziou, Paul; Simes, R John; Kesaniemi, Y Antero; Gebski, Val; Scott, Russell; Keech, Anthony CPublished 2011-02-01Abstract Aims/hypothesis Fenofibrate caused an acute, sustained plasma creatinine increase in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and Action to Control Cardiovascular Risk in Diabetes ...Open AccessPost-print -
Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
D'Emden, Michael C; Jenkins, Alicia J; Li, Liping; Zannino, Diana; Mann, Kristy P; Best, James D; Stuckey, Bronwyn GA; Park, Kris; Saltevo, Juha; Keech, Anthony CPublished 2014-08-23Aims/hypothesis In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n=9795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in ...Open AccessArticle -
Inappropriate sinus tachycardia: focus on ivabradine
Abed, Hany S; Fulcher, Jordan; Kilborn, Michael J; Keech, Anthony CPublished 2016-04-10Inappropriate sinus tachycardia (IST) is an incompletely understood condition characterised by an elevation in heart rate (HR) accompanied by wide ranging symptoms, in the absence of an underlying physiological stimulus. ...Open AccessArticle -
Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes: analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Williams, Kathryn H; Sullivan, David R; Nicholson, Geoffrey C; George, Jacob; Jenkins, Alicia J; Januszewski, Andrzej S; Gebski, Val J; Manning, Patrick; Tan, Yong Mong; Donoghoe, Mark W; Ehnholm, Christian; Young, Simon; O'Brien, Richard; Buizen, Luke; Twigg, Stephen M; Keech, Anthony CPublished 2016-04-18Aims Reported associations between liver enzymes and mortality may not hold true in type 2 diabetes, owing to a high prevalence of non-alcoholic fatty liver disease, which has been linked to cardiovascular disease and ...Open AccessArticle -
Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study
Herrman, Marcus; Whiting, Malcom J; Veillard, Anne-Sophie; Ehnholm, Christian; Sullivan, David R; Keech, Anthony CPublished 2012-07-15Background The lipid-lowering effect of fenofibrate is accompanied by a rise in plasma homocysteine, a potential risk factor for venous thromboembolism (VTE). This study investigated the relationship between homocysteine ...Open AccessArticle -
QT interval, corrected for heart rate, is associated with HbA concentration and autonomic function in diabetes
Stern, K; Cho, Y.H.; Benitez-Aguirre, P; Jenkins, Alicia J.; McGill, M; Mitchell, Paul; Keech, Anthony C; Donaghue, Kim CPublished 2016-01-30Aims To examine QT intervals corrected for heart rate (QTc) in adolescents with Type 1 diabetes compared with control subjects, and to determine associations with metabolic control and autonomic function. Methods Resting ...Open AccessArticle -
Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study
Hankey, Graeme J; Anderson, Neil E; Ting Ru-Dee; Veillard, Anne-Sophie; Romo, Matti; Wosik, Melinda; Sullivan, David R; O'Connell, Rachel L; Hunt, David; Keech, Anthony CPublished 2012-10-20Background Small vessel disease is reported to be a more common cause of ischaemic stroke in people with diabetes than in others. However, population based studies have shown no difference between those with and those ...Open AccessArticle -
The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study
Ong, Kwok-Leung; Januszewski, Andrzej S; O'Connell, Rachel; Jenkins, Alicia J; Xu, Aimin; Sullivan, David R; Barter, Philip J; Hung, Wei-Ting; Scott, Russell S; Taskinen, Marja-Riitta; Keech, Anthony C; Rye, Kerry-AnnePublished 2014-11-26Aims/hypothesis Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. This study investigated the relationship of plasma FGF21 levels ...Open AccessArticle -
Serum 25-hydroxy vitamin D: a predictor of macrovascular and microvascular complications in patients with type 2 diabetes
Herrman, Markus; Sullivan, David R; Veillard, Anne-Sophie; McCorquodale, Thomas; Straub, Isabella R; Scott, Russell; Laakso, Markku; Topliss, Duncan; Jenkins, Alicia J; Blankenberg, Stefan; Burton, Anthony; Keech, Anthony CPublished 2014-12-20Objective People with diabetes frequently develop vascular disease. We investigated the relationship between blood 25-hydroxy vitamin D (25OH-D) concentration and vascular disease risk in type 2 diabetes. Research design ...Open AccessArticle
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