Browsing by author "Irwig, Les"
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48 Trends in stage-specific breast cancer incidence in new south wales, australia: insights from 25 years of screening mammography
Jacklyn, Gemma; McGeechan, Kevin; Irwig, Les; Houssami, Nehmat; Morrell, Stephen; Bell, Katy J.L.; Barratt, Alexandra LPublished 2018Screening mammography aims to improve breast cancer (BC) prognosis by increasing the incidence of early-stage tumours in order to decrease the incidence of late-stage cancer, but no reports have investigated these potential ...Conference paper -
Assessing the Potential for Patient-led Surveillance After Treatment of Localized Melanoma (MEL-SELF) A Pilot Randomized Clinical Trial
Ackermann, Deonna M; Dieng, Mbatho; Medcalf, Ellie; Jenkins, Marisa C; van Kemenade, Cathelijne H; Janda, Monika; Turner, Robin M; Cust, Anne E; Morton, Rachael L; Irwig, Les; Guitera, Pascale; Soyer, Peter; Mar, Victoria; Hersch, Jolyn; Low, Donald; Low, Cynthia; Saw, Robyn P. M; Scolyer, Richard A; Drabarek, Dorothy; Espinoza, David; Azzi, Anthony; Lilleyman, Alister M; Smit, Amelia K; Murchie, Peter; Thompson, John F; Bell, Katy J.L.Published 2022Patient-led surveillance is a promising new model of follow-up care following excision of localized melanoma. Objective To determine whether patient-led surveillance in patients with prior localized primary cutaneous ...Open AccessArticle -
Assessment of changes to screening programmes: why randomisation is important
Bell, Katy J.L.; Bossuyt, Patrick; Glasziou, Paul; Irwig, LesPublished 2015Screening programmes sometimes need to be adapted as new technologies and treatments become available. Katy Bell and colleagues argue the best way to assess such changes is through randomised trials within the programmesArticle -
The Association of Surgical Margins and Local Recurrence in Women with Ductal Carcinoma In Situ Treated with Breast-Conserving Therapy: A Meta-Analysis.
Marinovich, Michael Luke; Azizi, Lamiae; Macaskill, Petra; Irwig, Les; Morrow, Monica; Solin, Lawrence J.; Houssami, NehmatPublished 2016Purpose: There is no consensus on adequate negative margins in breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). We systematically reviewed the evidence on margins in BCS for DCIS. Methods: A study-level ...Article -
Can Patient-Led Surveillance Detect Subsequent New Primary or Recurrent Melanomas and Reduce the Need for Routinely Scheduled Follow Up? A Protocol for the MELSELF Randomised Controlled Trial.
Ackermann, Deonna; Smit, Amelia K; Janda, Monika; van Kemenade, Cathelijne; Dieng, Mbathio; Morton, Rachael L; Turner, Robin M; Cust, Anne E; Irwig, Les; Hersch, Jolyn; Guitera, Pascale; Soyer, Peter; Mar, Victoria; Saw, Robyn PM; Low, Donald; Low, Cynthia; Drabarek, Dorothy; Espinoza, David; Emery, Jon; Murchie, Peter; Thompson, John F; Scolyer, Richard; Azzi, Anthony; Lilleyman, Alister; Bell, Katy J.L.Published 2021Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). Routinely scheduled ...Open AccessPreprint -
Can patient-led surveillance detect subsequent new primary or recurrent melanomas and reduce the need for routinely scheduled follow-up? A protocol for the MEL-SELF randomised controlled trial
Ackermann, Deonna M.; Smit, Amelia K.; Janada, Monika; van Kemenade, Cathelijne H.; Dieng, Mbathio; Morton, Rachael L.; Turner, Robin M.; Cust, Anne E.; Irwig, Les; Hersch, Jolyn K.; Guitera, Pascale; Soyer, H. Peter; Mar, Victoria; Saw, Robyn P.M.; Low, Donald; Low, Cynthia; Drabarek, Dorothy; Espinoza, David; Emery, Jon; Murchie, Peter; Thompson, John F.; Scolyer, Richard A.; Azzi, Anthony; Lilleyman, Alister; Bell, Katy J.L.Published 2021Background Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). ...Open AccessArticle -
Carcinoma in situ of the breast in New South Wales, Australia: Current status and trends over the last 40 year.
Jacklyn, Gemma; Morrell, Stephen; McGeechan, Kevin; Houssami, Nehmat; Irwig, Les; Pathmanathan, Nirmala; Barratt, AlexandraPublished 2017The incidence of non-invasive breast cancer has increased substantially over time. We aim to describe temporal trends in the incidence of carcinoma in situ of the breast in New South Wales (NSW), Australia. Descriptive ...Article -
Communicating cardiovascular disease risk: an interview study of General Practitioners’ use of absolute risk within tailored communication strategies
Bonner, Carissa; Jansen, Jesse; McKinn, Shannon; Irwig, Les; Doust, Jenny; Glasziou, Paul; McCaffery, KirstenPublished 2014-05-29Background: Cardiovascular disease (CVD) prevention guidelines encourage assessment of absolute CVD risk - the probability of a CVD event within a fixed time period, based on the most predictive risk factors. However, few ...Open AccessArticle -
A Counterargument to Encounter Frequency and Target Achievement: Measurement Variability
Hayen, Andrew; Bell, Katy J.L.; Glasziou, Paul; Irwig, LesPublished 2012Editorial response to the conclusion of the recent report by Morrison and colleagues that encounter frequency leads to apparent better control of glucose (hemoglobin A1c), blood pressure, and low-density lipoprotein ...Article, Letter -
COVID-19: how many Australians might have died if we’d had an outbreak like that in England and Wales?
Stanaway, Fiona; Irwig, Les; Teixeira-Pinto, Armando; Bell, Katy J.L.Published 2020Using all-cause mortality data in England and Wales over the peak of the COVID-19 outbreak in March and April, we directly estimated the number of excess deaths that may have occurred if the outbreak in Australia had been ...Open AccessArticle -
Criteria for monitoring tests were described: validity, responsiveness, detectability of long-term change, and practicality
Bell, Katy J.L.; Glasziou, Paul; Hayen, Andrew; Irwig, LesPublished 2014Objective: To describe how evidence from trials and cohort studies may be used to guide choice of test for monitoring patients with chronic disease. Study Design and Setting: Exploration of potential criteria for ...Article -
Early CRT monitoring using time-domain optical coherence tomography does not add to visual acuity for predicting visual loss in patients with central retinal vein occlusion treated with intravitreal Ranibizumab
Bell, Katy J.L.; Hayen, Andrew; Glasziou, Paul; Mitchell, Andrew S; Farris, Maria; Wright, Jonathan; Duerr, Hans-Peter; Mitchell, Paul; Irwig, LesPublished 2017Our primary purpose was to assess the clinical (predictive) validity of central retinal thickness (CRT) and best corrected visual acuity (BCVA) at 1 week and 1 month after starting treatment with ranibizumab for central ...Open AccessArticle -
The effect of information about overdetection of breast cancer on women's decision-making about mammography screening: Study protocol for a randomised controlled trial
Hersch, Jolyn; Barratt, Alexandra; Jansen, Jesse; Houssami, Nehmat; Irwig, Les; Jacklyn, Gemma; Dhillon, Haryana; Thornton, Hazel; McGeechan, Kevin; Howard, Kirsten; McCaffery, KirstenPublished 2014-05-15Introduction: Women are largely unaware that mammography screening can cause overdetection of inconsequential disease, leading to overdiagnosis and overtreatment of breast cancer. Evidence is lacking about how information ...Open AccessArticle -
Effects of additional blood pressure and lipid measurements on the prediction of cardiovascular risk
Bell, Katy J.L.; Hayen, Andrew; McGeechan, Kevin; Neal, Bruce; Irwig, LesPublished 2012Current guidelines recommend that decisions to start preventative therapy for cardiovascular disease (CVD) should be based on absolute risk; however, current risk equations are based on single measurements of risk factors. ...Article -
Equity and evidence during vaccine rollout: stepped wedge cluster randomised trials could help.
Bell, Katy J.L.; Glasziou, Paul; Stanaway, Fiona; Bossuyt, Patrick; Irwig, LesPublished 2021Letter re allocating scarce vaccines, For groups of equivalent priority, a fair and equitable way to decide on the order of rollout is to use a lottery, or system of random choice. Such randomised sequentialrollout of ...Open AccessArticle -
Estimating the potential impact of interventions to reduce over‐calling and under‐calling of melanoma
Gibson, Matthew W; Scolyer, Richard; Soyer, Peter H; Ferguson, Peter M; McGeechan, Kevin; Irwig, Les; Bell, Katy J.L.Published 2021Pathologists sometimes disagree over the histopathologic diagnosis of melanoma. ‘Over‐calling’ and ‘under‐calling’ of melanoma may harm individuals and healthcare systems. The objective of this study was to estimate the ...Article -
Factors influencing general practitioners’ decisions about cardiovascular disease risk reassessment: findings from experimental and interview studies
McKinn, Shannon; Bonner, Carissa; Jansen, Jesse; Teixeira-Pinto, Armando; So, Matthew; Irwig, Les; Doust, Jenny; Glasziou, Paul; McCaffery, KirstenPublished 2016-08-05Background: Guidelines on cardiovascular disease (CVD) risk reassessment intervals are unclear, potentially leading to detrimental practice variation: too frequent can result in overtreatment and greater strain on the ...Open AccessArticle -
Fear of New or Recurrent Melanoma After Treatment for Localised Melanoma
Bell, Katy J.L.; Mehta, Yachna; Turner, Robin M; Morton, Rachael M; Dieng, Mbathio; Saw, Robyn; Guitera, Pascale; McCaffery, Kirsten; Low, Donald; Low, Cynthia; Jenkins, Marisa; Irwig, Les; Webster, Angela CPublished 2017-01-01Objective: To estimate the amount of fear of new or recurrent melanoma among people treated for localised melanoma in an Australian specialist centre. Methods: We randomly selected 400 potential participants from all those ...Open AccessArticle -
Follow-up of early stage melanoma: specialist clinician perspectives on the functions of follow-up and implications for extending follow-up intervals
Rychetnik, Lucie; McCaffery, Kirsten; Morton, Rachael L; Thompson, John; Menzies, Scott; Irwig, LesPublished 2012-10-22BACKGROUND: There is limited evidence on the relative effectiveness of different follow-up schedules for patients with AJCC stage I or II melanoma, but less frequent follow-up than is currently recommended has been proposed. ...Open AccessArticle -
General practitioners’ decision making about primary prevention of cardiovascular disease in older adults: a qualitative study
Jansen, Jesse; McKinn, Shannon; Bonner, Carissa; Irwig, Les; Doust, Jenny; Glasziou, Paul; Bell, Katy J.L.; Naganathan, Vasi; McCaffery, KirstenPublished 2017-01-13Background: Primary cardiovascular disease (CVD) prevention in older people is challenging as they are a diverse group with varying needs, frequent presence of comorbidities, and are more sus- ceptible to treatment harms. ...Open AccessArticle
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