Browsing by author "Irish, Muireann"
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Addenbrooke’s Cognitive Examination III: Psychometric Characteristics and Relations to Functional Ability in Dementia
So, Matthew; Foxe, David; Kumfor, Fiona; Murray, Cynthia; Hsieh, Sharpley; Savage, Greg; Ahmed, Rebekah M.; Burrell, James R.; Hodges, John R.; Irish, Muireann; Piguet, OlivierPublished 2018-09-07Objectives: The Addenbrooke’s Cognitive Examination (ACE) is a common cognitive screening test for dementia. Here, we examined the relationship between the most recent version (ACE-III) and its predecessor (ACE-R), determined ...Open AccessArticle -
Age-related changes in the temporal focus and self-referential content of spontaneous cognition during periods of low cognitive demand
Irish, Muireann; Goldberg, Zoe-Lee; Alaeddin, Sara; O’Callaghan, Claire; Andrews-Hanna, Jessica R.Published 2019-09-18An intriguing aspect of human cognition is the unique capacity to mentally retreat from our immediate surroundings to consider perspectives distinct from the here and now. Despite increasing interest in this phenomenon, ...Open AccessArticle -
"All is not lost” - Rethinking the nature of memory and the self in dementia
Strikwerda-Brown, C.; Grilli, M.D.; Andrews-Hanna, J.R.; Irish, MuireannPublished 2019-09-18Memory and the self have long been considered intertwined, leading to the assumption that without memory, there can be no self. This line of reasoning has led to the misconception that a loss of memory in dementia necessarily ...Open AccessArticle -
Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome
Ahmed, Samrah; Irish, Muireann; Loane, Clare; Baker, Ian; Husain, Masud; Thompson, Sian; Blanco-Duque, Cristina; Mackay, Clare; Zamboni, Giovanna; Foxe, David; Hodges, John R.; Piguet, Olivier; Butler, ChristopherPublished 2018-03-10Posterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria ...Open AccessArticle -
Cerebellar Atrophy and Its Contribution to Cognition in Frontotemporal Dementias
Chen, Yu; Kumfor, Fiona; Landin-Romero, Ramon; Irish, Muireann; Hodges, John R.; Piguet, OlivierPublished 2018-06-07Objective: Increasing evidence suggests that cerebellar damage impacts on cognitive functions. Frontotemporal dementias (FTDs) are neurodegenerative brain conditions, primarily affecting the frontal and/or temporal lobe. ...Open AccessArticle -
The cerebellum in frontotemporal dementia: a meta-analysis of neuroimaging studies
Chen, Y.; Kumfor, F.; Landin-Romero, R.; Irish, Muireann; Piguet, O.Published 2019-08-19Frontotemporal dementia (FTD) is a neurodegenerative brain disorder primarily affecting the frontal and/or temporal lobes. Three main subtypes have been recognized: behavioural-variant FTD (bvFTD), semantic dementia (SD) ...Article -
Exploring the contribution of visual imagery to scene construction – evidence from Posterior Cortical Atrophy
Ramanan, Siddharth; Alaeddin, Sara; Goldberg, Zoe-Lee; Strikwerda-Brown, Cherie; Hodges, John R.; Irish, MuireannPublished 2018-09-01Posterior Cortical Atrophy (PCA) is a rare neurodegenerative syndrome characterised by profound visuoperceptual processing disturbances, attributable to focal parieto-occipital cortical atrophy. Despite relative sparing ...Open AccessArticle -
External details revisited – A new taxonomy for coding ‘non-episodic’ content during autobiographical memory retrieval
Strikwerda-Brown, Cherie; Mothakunnel, Annu; Hodges, John R.; Piguet, Olivier; Irish, MuireannPublished 2018-04-24Autobiographical memory is typically held to comprise episodic and semantic elements, with the vast majority of studies to date focusing on profiles of episodic details in health and disease. In this context, ‘non-episodic’ ...Open AccessArticle -
Fronto-parietal contributions to episodic retrieval – evidence from neurodegenerative disorders
Ramananan, Siddharth; Strikwerda-Brown, Cherie; Mothakunnelel, Annu; Hodges, John R.; Piguet, Olivier; Irish, MuireannPublished 2019-06-01Converging evidence suggests a critical role for the parietal cortices in episodic memory retrieval. Here, we examined episodic memory performance in Corticobasal Syndrome (CBS), a rare neurodegenerative disorder presenting ...Open AccessArticle -
The function of prospection - variations in health and disease
Bulley, Adam; Irish, MuireannPublished 2018-11-27Much of human life revolves around anticipating and planning for the future. It has become increasingly clear that this capacity for prospective cognition is a core adaptive function of the mind. Here, we review the role ...Open AccessArticle -
Hippocampal atrophy and intrinsic brain network alterations relate to impaired capacity for mind wandering in neurodegeneration
O’Callaghan, C.; Shine, J.M.; Hodges, J.R.; Andrews-Hanna, J.R.; Irish, MuireannPublished 2019-09-18Mind wandering represents the human capacity for internally focussed thought, and relies upon dynamic interactions between default and frontoparietal networks. The majority of studies in the field have characterised mind ...Open AccessArticle -
Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
Strikwerda-Brown, Cherie; Ramanan, Siddharth; Irish, MuireannPublished 2019-02-20Much of human interaction is predicated upon our innate capacity to infer the thoughts, beliefs, emotions, and perspectives of others, in short, to possess a “theory of mind” (ToM). While the term has evolved considerably ...Open AccessArticle -
The other side of the coin – Semantic dementia as a lesion model for understanding recollection and familiarity
Strikwerda-Brown, C.; Irish, MuireannPublished 2019-09-18The syndrome of semantic dementia represents the “other side of the coin” to Alzheimer’s disease, offering convergent evidence to help refine Bastin et al.’s Integrative Memory Model. By considering the Integrative Memory ...Open AccessArticle, Letter -
Rethinking the role of the angular gyrus in remembering the past and imagining the future - the Contextual Integration Model
Ramanan, Siddharth; Piguet, Olivier; Irish, MuireannPublished 2017-10-18Despite consistent activation on tasks of episodic memory, the precise contribution of the left angular gyrus (AG) to mnemonic functions remains vigorously debated. Mounting evidence suggests that AG activity scales with ...Open AccessArticle -
"Truth be told” – Semantic memory as the scaffold for veridical communication
Hayes, Brett K.; Ramanan, Siddharth; Irish, MuireannPublished 2018-01-22Theoretical accounts placing episodic memory as central to constructive and communicative functions neglect the role of semantic memory. We argue that the decontextualized nature of semantic schemas largely supersedes the ...Open AccessArticle, Letter -
Visuospatial dysfunction in Alzheimer’s disease and behavioural variant frontotemporal dementia
Salimi, S.; Irish, Muireann; Foxe, D.; Hodges, J.R.; Piguet, O.; Burrell, J.R.Published 2019-09-18OBJECTIVES: Approximately 30% of Alzheimer’s disease (AD) patients are misdiagnosed due to overlapping and evolving clinical features. In particular, the distinction of AD from behavioural variant frontotemporal dementia ...Open AccessArticle
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