• Acute low back pain is marked by variability: An internet-based pilot study 

      Suri, Pradeep; Rainville, James; Fitzmaurice, Garrett M; Katz, Jeffrey N.; Jamison, Robert N; Martha, Julia; Hartigan, Carol; Limke, Janet; Jouve, Cristin; Hunter, David J.
      Published 2011-10-05
      BACKGROUND: Pain variability in acute LBP has received limited study. The objectives of this pilot study were to characterize fluctuations in pain during acute LBP, to determine whether self-reported 'flares' of pain ...
      Open Access
      Publisher version
    • Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea 

      Kim, I. J.; Kim, D. H.; Jung, J. Y.; Song, Y. W.; Guermazi, Ali; Crema, M. D.; Hunter, David J.; Kim, H. A.
      Published 2013-05-01
      Objective: To describe the frequency of bonemarrowlesions (BMLs) detected bymagnetic resonance imaging (MRI), and to examine the association of BMLs with knee pain severity in community residents in Korea. Methods: ...
      Open Access
      Article
    • The association between reduced knee joint proprioception and medial meniscal abnormalities using MRI in knee osteoarthritis: results from the Amsterdam osteoarthritis cohort. 

      van der Esch, Martin; Knoop, Jesper; Hunter, David J.; Klein, Jan-Paul; van der Leeden, Marike; Knol, Dirk L; Reiding, Dick; Vooreman, Ramon E; Gerritsen, Martijn; Roorda, Leo D; Lems, Willem F; Dekker, Joost
      Published 2013-05-01
      BACKGROUND: Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of ...
      Open Access
      Article
    • Disease-modifying drugs for knee osteoarthritis: can they be cost-effective? 

      Losina, Elena; Daigle, Meghan E.; Reichmann, William M.; Suter, Lisa G.; Hunter, David J.; Solomon, Daniel H.; Walensky, Rochelle P.; Jordan, Joanne M.; Burbine, Sara A.; Patiel, A. Daniel; Katz, Jeffrey N.
      Published 2013-05-01
      OBJECTIVE: Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment. DESIGN: ...
      Open Access
      Article
    • Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population 

      Suri, Pradeep; Miyakoshi, Asako; Hunter, David J.; Jarvik, Jeffrey G; Rainville, James; Guermazi, Ali; Li, Ling; Katz, Jeffrey N.
      Published 2011-09-13
      Background- Prior studies that have concluded that disk degeneration uniformly precedes facet degeneration have been based on convenience samples of individuals with low back pain. We conducted a study to examine whether ...
      Open Access
      Article
    • EFFECTS OF INTENSIVE DIET AND EXERCISE ON KNEE JOINT LOADS, INFLAMMATION, AND CLINICAL OUTCOMES AMONG OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS 

      Messier, Stephen P; Mihalko, Shannon L; Legault, Claudine; Miller, Gary D.; Nicklas, Barbara J.; DeVita, Paul; Beavers, Daniel P; Hunter, David J.; Lyles, Mary F.; Eckstein, Felix; Williamson, Jeff D; Carr, J. Jeffery; Guermazi, Ali; Loeser, Richard F.
      Published 2013-01-01
      Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body weight ...
      Open Access
      Article
    • The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament 

      Riordan, Edward A; Frobell, Richard B; Roemer, Frank W.; Hunter, David J.
      Published 2013-02-01
      Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...
      Open Access
      Article
    • Imaging Biomarker Validation and Qualification Report: 6th OARSI Workshop on Imaging in Osteoarthritis Combined with 3rd OA Biomarkers Workshop. 

      Hunter, David J.; Eckstein, Felix; Kraus, Virginia Byers; Lousina, Elena; Sandell, Linda; Guermazi, Ali
      Published 2013-07-01
      Summary The sixth Osteoarthritis Research Society International (OARSI) Workshop on Imaging in Osteoarthritis combined with the third osteoarthritis (OA) Biomarkers Workshop is the first to bring together the imaging and ...
      Open Access
      Article
    • Imaging of Osteoarthritis 

      Guermazi, Ali; Hayashi, Daichi; Eckstein, Felix; Hunter, David J.; Duryea, Jeff; Roemer, Frank W.
      Published 2013-02-01
      Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral ...
      Open Access
      Article
    • Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US 

      Losina, Elena; Weinstein, Alexander M.; Reichmann, William M.; Burbine, Sara A.; Solomon, Daniel H.; Daigle, Meghan E.; Rome, Benjamin N.; Chen, Stephanie P.; Hunter, David J.; Suter, Lisa G.; Jordan, Joanne M.; Katz, Jeffrey N.
      Published 2013-05-01
      OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...
      Open Access
      Article
    • Long term joint consequences of sporting activity: preventing and managing osteoarthritis in the athlete 

      Bennell, Kim L; Hunter, David J.; Vicenzino, Bill
      Published 2012-07-31
      Sports participation is associated with an increased risk of future osteoarthritis (OA), much of which results from joint injury. No strong evidence exists that moderate sporting activity in the presence of normal joints ...
      Open Access
      Article
    • Management of osteoarthritis of the knee 

      Bennell, Kim L; Hunter, David J.; Hinman, Rana S
      Published 2012-07-30
      Osteoarthritis is a chronic disease; management should be patient centred and coordinated, with attention to modifiable risk factors and comorbidities Focus on conservative non-drug treatment, particularly exercise; for ...
      Open Access
      Article
    • The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features 

      Katz, Jeffrey N.; Chaisson, Christine E; Cole, Brian; Guermazi, Ali; Hunter, David J.; Jones, Morgan; Levy, Bruce A; Mandi, Lisa A; Martin, Scott; Marx, Robert G; Safran-Norton, Clare; Roemer, Frank W.; Skoniecki, Debra; Solomon, Daniel H.; Spindler, Kurt P.; Wright, John; Wright, Rick W; Losina, Elena
      Published 2012-11-01
      This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...
      Open Access
      Article
    • Morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis of the knee. 

      Hwang, Seung Hyun; Jung, Kwang-Am; Lee, Won Jun; Yang, Ki Hyuk; Lee, Dong Won; Carter, Aaron; Hunter, David J.
      Published 2012-02-01
      OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...
      Open Access
      Article
    • Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. 

      Williams, Frances M K; Bansal, Aruna T; van Meurs, Joyce B; Bell, Jordana T; Meulenbelt, Ingrid; Suri, Pradeep; Rivadeneira, Fernando; Sambrook, Philip N; Hofman, Albert; Bierm-Zeinstra, Sita; Menni, Cristina; Kloppenburg, Megreet; Slagboom, P Eline; Hunter, David J.; MacGregor, Alex J; Uitterlinden, Andre G.; Spector, Tim D
      Published 2013-07-01
      OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. ...
      Open Access
      Article
    • Osteoarthritis Preface 

      Hunter, David J.
      Published 2013-02-01
      Osteoarthritis (OA) is the leading cause of disability among older adults. It is an incredibly prevalent condition affecting upward of 1 in 8 adults. Societal trends in aging, obesity, and increasing joint injury will lead ...
      Open Access
      Article
    • Osteoarthritis: What does imaging tell us about its etiology. 

      Johnson, Victoria L; Giuffre, Bruno M; Hunter, David J.
      Published 2012-11-01
      Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Due to an aging population and increasing obesity, the incidence of OA is rising. The etiology of OA is multifactorial and complex; ...
      Open Access
      Article
    • Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears. 

      Stein, Verena; Li, Ling; Guermazi, Ali; Zhang, Yuqing; Kwoh, C. Kent; Eaton, Charles B; Hunter, David J.
      Published 2012-02-01
      OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...
      Open Access
      Article
    • Presence and Extent of Severe Facet Joint Osteoarthritis Are Associated with Back Pain in Older Adults 

      Suri, Pradeep; Hunter, David J.; Rainville, James; Guermazi, Ali; Katz, Jeffrey N.
      Published 2013-09-01
      Objective To determine whether the presence and extent of severe lumbar facet joint osteoarthritis (OA) are associated with back pain in older adults, accounting for disc height narrowing and other covariates. Design ...
      Open Access
      Article
    • Prevalence of Anatomic Impediments to Interlaminar Lumbar Epidural Steroid Injection 

      Hameed, Farah; Hunter, David J.; Rainville, James; Li, Ling; Suri, Pradeep
      Published 2012-02-01
      OBJECTIVE: To determine the prevalence of anatomic impediments to interlaminar lumbar epidural steroid injection (LESI) in a community-based population. DESIGN: Cross-sectional observational study. SETTING: Community-based. ...
      Open Access
      Article