• Advances in Anion Receptor Chemistry 

      Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.
      Published 2020
      This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...
      Embargoed
      Article
    • Anion receptor chemistry: Highlights from 2016 

      Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.
      Published 2018-02-01
      This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.
      Open Access
      Article
    • Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate 

      Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, Luke
      Published 2017-02-01
      Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...
      Open Access
      Article
    • Development of a library of thiophene-based drug-like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity 

      Vieira, Paulo; Miranda, Margarida Q.; Marques, Igor; Carvalho, Sílvia; Li-Jun, Chen; Howe, Ethan N.W.; Zhen, Carl; Leung, Claudia Y.; Spooner, Michael J.; Morgado, Bárbara; da Cruz e Silva, Odete A.B.; Moiteiro, Cristina; Gale, Philip A.; Félix, Vítor
      Published 2020
      The anion binding and transport properties of an extensive library of thiophene-based molecules are reported. Seventeen bis-urea positional isomers, with different binding conformations and lipophilicities, were synthetized ...
      Open Access
      Article
    • Fatty Acid Fueled Transmembrane Chloride Transport 

      Howe, Ethan N.W.; Gale, Philip A.
      Published 2019-06-21
      Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump ...
      Open Access
      Article
    • Fluorescent squaramides as anion receptors and transmembrane anion transporters 

      Bao, Xiaoping; Wu, Xin; Berry, Stuart N.; Howe, Ethan N.W.; Chang, Young-Tae; Gale, Philip A.
      Published 2018-01-01
      A series of squaramide-based anion transporters functionalised with the 1,8-naphthalimide fluorophore has been developed for improved ionophoric activity and fluorescent imaging in cells.
      Open Access
      Article
    • Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport 

      Spooner, Michael J.; Li, Hongyu; Marques, Igor; Costa, Pedro M.R.; Wu, Xin; Howe, Ethan N.W.; Busschaert, Nathalie; Moore, Stephen J.; Light, Mark E.; Sheppard, David N.; Gale, Philip A.
      Published 2018-01-01
      A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in cells ...
      Open Access
      Article
    • Fluorinated tripodal receptors for potentiometric chloride detection in biological fluids 

      Pankratova, Nadezda; Cuartero, Maria; Jowett, Laura A.; Howe, Ethan N.W.; Gale, Philip A.; Bakker, Eric; Crespo, Gastón A.
      Published 2017-07-01
      Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective ...
      Open Access
      Article
    • Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations 

      Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, Vítor
      Published 2018-01-01
      A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...
      Open Access
      Article
    • Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations 

      Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, Vítor
      Published 2018-06-29
      A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...
      Open Access
      Article
    • Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents 

      Jowett, Laura A.; Howe, Ethan N.W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Pérez-Tomás, Ricardo; Gale, Philip A.
      Published 2017-01-01
      Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...
      Open Access
      Article
    • Investigating the Influence of Steric Hindrance on Selective Anion Transport 

      Jowett, Laura A.; Ricci, Angela; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.
      Published 2019-04-02
      A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents ...
      Open Access
      Article
    • New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas 

      Jowett, Laura A.; Howe, Ethan N.W.; Wu, Xin; Busschaert, Nathalie; Gale, Philip A.
      Published 2018-06-19
      The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism ...
      Open Access
      Article
    • Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux 

      Zhang, Shaoyi; Wang, Yan; Xie, Wei; Howe, Ethan N.W.; Busschaert, Nathalie; Sauvat, Allan; Leduc, Marion; Gomes-da-Silva, Ligia C.; Chen, Guo; Martins, Isabelle; Deng, Xiaxing; Maiuri, Luigi; Kepp, Oliver; Soussi, Thierry; Gale, Philip A.; Zamzami, Naoufal; Kroemer, Guido
      Published 2019-02-01
      Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate ...
      Open Access
      Article
    • Stimuli-responsive cycloaurated ‘OFF-ON’ switchable anion transporters 

      Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A.; Howe, Ethan N.W.; Pérez-Tomás, Ricardo; Gale, Philip A.
      Published 2020
      Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes ...
      Embargoed
      Article