Browsing by author "Harmer, Christopher J"
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The A to Z of A/C Plasmids
Harmer, Christopher J; Hall, Ruth MPublished 2015-04-21Plasmids belonging to incompatibility groups A and C (now A/C) were among the earliest to be associated with antibiotic resistance in Gram-negative bacteria. A/C plasmids are large, conjugative plasmids with a broad host ...Open AccessArticle -
Evolution and typing of IncC plasmids contributing to antibiotic resistance in Gram-negative bacteria
Ambrose, Stephanie J; Harmer, Christopher J; Hall, Ruth MPublished 2018-12-14The large, broad host range IncC plasmids are important contributors to the spread of key antibiotic resistance genes and over 200 complete sequences of IncC plasmids have been reported. To track the spread of these plasmids ...Open AccessArticle -
Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung
Harmer, Christopher J; Wynn, Matthew; Pinto, Rachel; Cordwell, Stuart; Rose, Barbara R; Harbour, Colin; Triccas, James A; Manos, JimPublished 2015-08-07Some Pseudomonas aeruginosa strains including Australian Epidemic Strain-1 (AES-1 or AUS-01) cause persistent chronic infection in cystic fibrosis (CF) patients, with greater morbidity and mortality. Factors conferring ...Open AccessArticle -
IS26-Mediated Precise Excision of the IS26-aphA1a Translocatable Unit
Harmer, Christopher J; Hall, Ruth MPublished 2015-12-08We recently showed that, in the absence of RecA-dependent homologous recombination, the Tnp26 transposase catalyzes cointegrate formation via a conservative reaction between two preexisting IS26, and this is strongly ...Open AccessArticle -
Movement of IS26-Associated Antibiotic Resistance Genes Occurs via a Translocatable Unit That Includes a Single IS26 and Preferentially Inserts Adjacent to Another IS26
Harmer, Christopher J; Moran, Robert A; Hall, Ruth MPublished 2014-10-07TheinsertionsequenceIS26playsakeyroleindisseminatingantibioticresistancegenesinGram-negativebacteria, forming regions containing more than one antibiotic resistance gene that are flanked by and interspersed with copies of ...Open AccessArticle -
p39R861-4, a type 2 A/C2 plasmid carrying a segment from the A/C1 RA1
Anantham, S; Harmer, Christopher J; Hall, Ruth MPublished 2015-07-13The largest plasmid in the strain 39R861, which is used as a plasmid size standard, was recovered by conjugation and sequenced to determine its exact size. Plasmid p39R861-4 transferred at high frequency. Though reported ...Open AccessArticle -
Targeted conservative formation of cointegrates between two DNA molecules containing IS26 occurs via strand exchange at either IS end
Harmer, Christopher J; Hall, Ruth MPublished 2017-09-01We recently proposed a model for targeted, conservative cointegrate formation between DNA molecules each containing a copy of IS26, that involves Tnp26-catalyzed strand exchange occurring at either the two left ends or the ...Open AccessArticle -
A Type 2 A/C2 plasmid carrying the aacC4 apramycin resistance gene and the erm(42) erythromycin resistance gene recovered from two Salmonella enterica serovars
Harmer, Christopher J; Holt, Kathryn E; Hall, Ruth MPublished 2014-12-02Objective: To determine the relationships between RepA/C2 plasmids carrying several antibiotic resistance genes found in isolates of Salmonella enterica serovars Ohio and Senftenberg from pigs. Methods: Illumina HiSeq was ...Open AccessArticle
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