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Browsing by author "Handelsman, D"

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    • Association between pain and the frailty phenotype in older men: longitudinal results from the Concord Health and Ageing in Men Project (CHAMP) 

      Megale, R; Ferreira, M; Ferreira, P; Naganathan, V; Cumming, R; Hirani, V; Waite, L; Seibel, M; Le Couteur, D; Handelsman, D; Blyth, F
      Published 2018-02-21
      Objectives to determine whether pain increases the risk of developing the frailty phenotype and whether frailty increases the risk of developing chronic or intrusive pain, using longitudinal data. Design/Setting longitudinal ...
      Open Access
      Article
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    • Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project 

      Wright, F; Takehara, S; Stanaway, F; Naganathan, V; Blyth, F; Hirani, V; Le Couteur, D; Handelsman, D; Waite, L; Seibel, M; Cumming, R
      Published 2020-01-13
      Objective To investigate whether poorer oral health, tooth loss and lower usage of dental services are associated with depressive symptoms in older Australian men. Methods Cross‐sectional study of data collected from ...
      Article
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    • Associations of body composition trajectories with bone mineral density, muscle function, falls and fractures in older men: The Concord Health and Ageing in Men Project. 

      Scott, D; Seibel, M; Cumming, R; Naganathan, V; Blyth, F; Le Couteur, D; Handelsman, D; Hsu, B; Waite, L; Hirani, V
      Published 2019-08-13
      Background Weight loss increases fracture risk in older adults. We aimed to determine associations of 2-year body composition trajectories with subsequent falls and fractures in older men. Methods We measured appendicular ...
      Open Access
      Article
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    • Associations of impaired renal function with decline in muscle strength and muscle function in older men: findings from the CHAMP Study 

      Toyama, T; van den Broek-Best, O; Ohkuma, T; Handelsman, D; Waite, L; Seibel, M; Cumming, R; Naganathan, V; Sherrington, S; Hirani, V; Wang, A
      Published 2019-10-01
      Background Advanced kidney disease is associated with reduced muscle strength and physical performance. However, associations between early stages of renal impairment and physical outcomes are unclear. Methods The Concord ...
      Article
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    • Associations of Sarcopenic Obesity with the Metabolic Syndrome and Insulin Resistance over Five Years in Older Men: The Concord Health and Ageing in Men Project 

      Scott, D; Cumming, R; Naganathan, V; Blyth, F; Le Couteur, D; Handelsman, D; Seibel, M; Waite, L; Hirani, V
      Published 2018-07-15
      Purpose Previous cross-sectional studies investigating associations of sarcopenic obesity with metabolic syndrome (MetS) and insulin resistance have not utilised consensus definitions of sarcopenia. We aimed to determine ...
      Open Access
      Article
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    • Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project 

      Le Couteur, D; Ribeiro, R; Senior, A; Hsu, B; Hirani, V; Blyth, F; Waite, L; Simpson, S; Naganathan, V; Cumming, R; Handelsman, D
      Published 2019-08-01
      Increased blood levels of branched chain amino acids (BCAAs) have been associated with cardiometabolic risk factors. Here we studied 918 community dwelling older men to determine the relationship between BCAAs and other ...
      Article
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    • Caregiving and all-cause mortality in older men 2005–15: the Concord Health and Ageing in Men Project 

      Shu, C-C; Hsu, B; Cumming, R; Blyth, F; Waite, L; Le Couteur, D; Handelsman, D; Naganathan, V
      Published 2019-04-27
      Background while both negative and positive impacts of caregiving on health have been reported, findings regarding caregiver’s mortality may be biased by the lack of consideration of changes in their health and caregiving ...
      Open Access
      Article
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    • Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage 

      Handelsman, D; Desai, R; Seibel, M; Le Couteur, D; Cumming, R
      Published 2019-11-09
      Long-term studies investigating hormone-dependent cancers and reproductive health often require prolonged frozen storage of serum which assumes that the steroid molecules and measurements are stable over that time. Previous ...
      Open Access
      Article
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    • Community-dwelling men with dementia are at high risk of hip but not any other fracture: The Concord Health and Ageing in Men Project 

      Hsu, B; Bleicher, K; Waite, L; Naganathan, V; Blyth, F; Handelsman, D; Le Couteur, D; Seibel, M; Cumming, R
      Published 2018-08-30
      Aim The aim of the present longitudinal study of community‐dwelling older men was to examine the association between cognitive status at baseline, and falls, fractures and bone loss over time. Methods In the Concord Health ...
      Open Access
      Article
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    • Cross-sectional and longitudinal relationships between inflammatory biomarkers and frailty in community-dwelling older men: the Concord Health and Ageing in Men Project 

      Hsu, B; Hirani, V; Cumming, R; Naganathan, V; Blyth, F; Wright, F; Waite, L; Seibel, M; Handelsman, D; Le Couteur, D
      Published 2017-07-28
      Background Previous studies demonstrated associations between IL-6 and frailty, but associations between a wide range of cytokines, chemokines, and growth factors with prevalent and incident frailty has not been studied. ...
      Open Access
      Article
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    • Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP) 

      Ribero, R; Hirani, V; Senior, A; Gosby, A; Cumming, R; Blyth, F; Naganathan, V; Waite, L; Handelsman, D; Kendig, H; Seibel, M; Simpson, S; Stanaway, F; Allman-Farinelli, M; Le Couteur, D
      Published 2017-08-01
      The revised Dietary Guideline Index (DGI-2013) scores individuals’ diets according to their compliance with the Australian Dietary Guideline (ADG). This cross-sectional study assesses the diet quality of 794 community-dwelling ...
      Open Access
      Article
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    • Does combined osteopenia/osteoporosis and sarcopenia confer greater risk of falls and fracture than either condition alone in older men? The Concord Health and Ageing in Men Project 

      Scott, D; Seibel, M; Cumming, R; Naganathan, V; Blyth, F; Le Couteur, D; Handelsman, D; Waite, L; Hirani, V
      Published 2018-07-18
      Background It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so-called osteosarcopenia) are at greater risk of falls and fractures than those with either condition alone. Methods One thousand ...
      Open Access
      Article
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    • Drug Burden Index and change in cognition over time in community dwelling older men: the CHAMP study 

      Jamsen, K; Gnjidic, D; Hilmer, S; Ilomaki, J; Le Couteur, D; Blyth, F; Handelsman, D; Naganathan, V; Waite, L; Cumming, R; Bell, J
      Published 2017-03-01
      Objective: Anticholinergic and sedative medications are associated with acute cognitive impairment, but the long-term impact on change in cognition is unclear. This study investigated the effect of anticholinergic and ...
      Article
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    • Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project 

      Hsu, B; Cumming, R; Blyth, F; Naganathan, V; Waite, L; Le Couteur, D; Seibel, M; Handelsman, D
      Published 2017-09-15
      To determine whether calculated free testosterone (cFT) provides prognostic information independent of serum T for predicting morbidity and mortality in older men in cross-sectional and 5-year longitudinal analyses. We ...
      Open Access
      Article
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    • Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men 

      Hsu, B; Naganathan, V; Blyth, F; Hirani, V; Le Couteur, D; Waite, L; Seibel, M; Handelsman, D; Cumming, R
      Published 2020-01-01
      Objectives The types of medical conditions leading to hospitalization in frail older people have not been investigated. The objectives were to evaluate associations between frailty and (a) risk of all-cause and cause-specific ...
      Article
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    • Frailty and oral health: Findings from the Concord Health and Ageing in Men Project 

      Valdez, E; Wright, F; Naganathan, V; Milledge, K; Blyth, F; Hirani, V; Le Couteur, D; Handelsman, D; Waite, L; Cumming, R
      Published 2019-10-06
      Objective To examine whether frailty in older men is associated with poorer oral health and lower levels of dental service utilisation. Background Poor oral health has been associated with some frailty components. Less is ...
      Open Access
      Article
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    • Health status, health behaviours and anxiety symptoms of older male caregivers: Findings from the Concord Health and Ageing in Men Project 

      Shu, C-C; Cumming, R; Kendig, H; Blyth, F; Waite, L; Le Couteur, D; Handelsman, D; Naganathan, V
      Published 2017-02-16
      Objective To explore differences between older male caregivers and non‐caregivers on health status, health behaviours and well‐being, including symptoms of anxiety. Methods Data were collected through self‐completed ...
      Open Access
      Article
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    • Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community dwelling older men: The Concord Health and Ageing in Men Project 

      Hirani, V; Naganathan, V; Blyth, F; Le Couteur, D; Seibel, M; Waite, L; Handelsman, D; Cumming, R
      Published 2017-05-01
      Background to explore the longitudinal associations between body composition measures, sarcopenic obesity and outcomes of frailty, activities of daily living (ADL) and instrumental ADL (IADL) disability, institutionalisation ...
      Article
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    • Longitudinal associations between vitamin D metabolites and sarcopenia in older Australian men: The Concord Health and Ageing in Men Project 

      Hirani, V; Cumming, R; Naganathan, V; Blyth, F; Le Couteur, D; Hsu, B; Handelsman, D; Waite, L; Seibel, M
      Published 2017-12-01
      Background: To explore the associations between serum 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D) levels at baseline and incidence of sarcopenia over time in older Australian community-dwelling older men. ...
      Article
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    • Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70 years not taking statins 

      Gnanenthiran, S; Austin, C; Cumming, R; Brieger, D; Le Couteur, D; Waite, L; Handelsman, D; Naganathan, V; Kritharides, L; Blyth, F
      Published 2019-10-13
      Objective Low levels of total cholesterol (TC) are associated with adverse outcomes in older populations. Whether this phenomenon is independent of statin use is unknown. We investigated the association between low TC ...
      Open Access
      Article
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