Browsing by author "George, Jacob"
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Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B
Fahrtash-Bahin, Farzan; Kariyawasam, Viraj C; Gray, Timothy; Byth, Karen; George, Jacob; Douglas, MarkPublished 2013-01-01Abstract AIM: To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS: A retrospective analysis of treatment naive patients receiving ...Open AccessArticle -
Data. Hepatocyte-specific deletion of ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury
Scott, Christopher; Cha, Kuan; Rao, Renuka; Liddle, Christopher; George, Jacob; Gunton, Jenny. EPublished 2015-01-01Open AccessDataset -
Elevated Liver Enzymes and Mortality in Older Individuals: A Prospective Cohort Study
Mahady, Suzanne E; Wong, G; Turner, RM; Mitchell, P; Macaskill, P; Craig, JC; George, JacobPublished 2016-01-01Aim of the study: The aim of the study was to determine the excess risk of all-cause and cardiovascular mortality in older people with elevated liver enzymes [alanine transaminase (ALT) and gamma glutamyltransferase (GGT)]. ...Open AccessArticle -
Exercise and diet in the management of nonalcoholic fatty liver disease
Mahady, Suzanne E; George, JacobPublished 2016-01-01Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition worldwide, and is projected to become the leading cause for liver transplantation in the United States as early as 2020. The mainstay ...Open AccessArticle -
Fatal outcome in a liver transplant recipient with COVID-19
Huang, Jiao-Feng; Zheng, Kenneth I.; George, Jacob; Gao, HHai-Nv; Wei, RRu-Nan; Yan, Hua-Dong; Zheng, Ming-HuaPublished 2020Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplantation. We describe a case of COVID-19 in a patient who had transplantation ...Article -
Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response
Read, Scott A; Tay, Enoch; Shahidi, Mahsa; O'Connor, Kate; Booth, David; George, Jacob; Douglas, MarkPublished 2015-01-01Treatment of chronic hepatitis C virus (HCV) infection is evolving rapidly with the development of novel direct acting antivirals (DAAs), however viral clearance remains intimately linked to the hepatic innate immune system. ...Open AccessArticle -
Hepatitis C Virus Induces the Cannabinoid Receptor 1
van der Poorten, David; Shahidi, Mahsa; Tay, Enoch; Sesha, Jayshree; Tran, Kayla; McLeod, Duncan; Milliken, J; Ho, Vicki; Hebbard, Lionel; Douglas, Mark; George, JacobPublished 2010-01-01Background: Activation of hepatic CB1 receptors (CB1) is associated with steatosis and fibrosis in experimental forms of liver disease. However, CB1 expression has not been assessed in patients with chronic hepatitis C ...Open AccessArticle -
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Eslam, Mohammed; Hashem, Ahmed M; Leung, Reynold; Romero-Gomez, Manuel; Berg, Thomas; Dore, Gregory; Chan, Henry L K; Irving, William; Sheridan, David; Abate, Maria; Mangia, Alessandra; Weltman, Martin; Bugianesi, Elisabetta; Spengler, Ulrich; Shaker, Olfat; Fischer, Janett; Mollison, Lindsay; Cheng, Wendy; Powell, Elizabeth; Nattermann, Jacob; Riordan, Stephen; McLeod, Duncan; Armstrong, Nicola J.; Douglas, Mark; Liddle, Christopher; Booth, David R.; George, Jacob; Ahlenstiel, Golo; International Hepatitis C Genetics Consortium (IHCGC)Published 2015-01-01Open AccessArticle -
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Thabet, Khaled; Asimakopoulos, Anastasia; Shojaei, Maryam; Romero-Gomez, Manuel; Mangia, Alessandra; Irving, William L.; Berg, Thomas; Dore, Gregory J.; Grønbæk, Henning; Sheridan, David; Abate, Maria; Bugianes, Elisabetta; Weltman, Martin; Mollison, Lindsay; Cheng, Wendy; Riordan, Stephen; Fischer, Janett; Spengler, Ulrich; Nattermann, Jacob; Wahid, Ahmed; Rojas, Angela; White, Rose; Douglas, Mark; McLeod, Duncan; Powell, Elizabeth; Liddle, Christopher; van der Poorten, David; George, Jacob; Eslam, Mohammed; International Liver Disease Genetics ConsortiumPublished 2016-01-01Open AccessArticle -
Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes: analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Williams, Kathryn H; Sullivan, David R; Nicholson, Geoffrey C; George, Jacob; Jenkins, Alicia J; Januszewski, Andrzej S; Gebski, Val J; Manning, Patrick; Tan, Yong Mong; Donoghoe, Mark W; Ehnholm, Christian; Young, Simon; O'Brien, Richard; Buizen, Luke; Twigg, Stephen M; Keech, Anthony CPublished 2016-04-18Aims Reported associations between liver enzymes and mortality may not hold true in type 2 diabetes, owing to a high prevalence of non-alcoholic fatty liver disease, which has been linked to cardiovascular disease and ...Open AccessArticle -
Prevalence of elevated alanine transaminase in Australia and its relationship to metabolic risk factors: A cross-sectional study of 9,447 people
Mahady, Suzanne E; Gale, J; Macaskill, P; Craig, JC; George, JacobPublished 2017-01-01BACKGROUND AND AIM: Elevated alanine transaminase (ALT) is a strong predictor of metabolic syndrome, but there are few data from the Australian population. We aimed to determine the prevalence of elevated ALT and association ...Open AccessArticle
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