Browsing by author "Gale, Philip A."
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Acridinone-based anion transporters
McNaughton, Daniel A.; Macreadie, Lauren K.; Gale, Philip A.Published 2021The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea ...Open AccessArticle -
Advances in Anion Receptor Chemistry
Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2020-01-01This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...Open AccessArticle -
Advances in applied supramolecular technologies
Williams, George T.; Haynes, Cally J.E.; Fares, Mohamed; Caltagirone, Claudia; Hiscock, Jennifer; Gale, Philip A.Published 2021Supramolecular chemistry is a comparatively young field that to date has mainly been focused on building a foundation of fundamental understanding. With much progress in this area, researchers are seeking to apply this ...Open AccessArticle -
Advances in fluorescent and colorimetric sensors for anionic species
McNaughton, Daniel A.; Fares, Mohamed; Picci, Giacomo; Gale, Philip A.; Caltagirone, ClaudiaPublished 2021In this review we cover recent developments in fluorescent and colorimetric anion sensors. These systems employ a range of different non-covalent interactions including hydrogen- and halogen-bonding, Lewis acidic boron-based ...Open AccessPreprint -
Anion binding in metal-organic frameworks
Wu, Xin; Gale, Philip A.Published 2021Despite commonly being used as the host for gases, solvents and other neutral molecules, metal-organic frameworks (MOFs) have received recent attention as supramolecular anion binding hosts with a broad range of environmental ...Open AccessPreprint -
Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs†
Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.Published 2019-10-01Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...Open AccessArticle -
Anion receptor chemistry: Highlights from 2016
Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.Published 2018-02-01This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.Open AccessArticle -
Anion transport and supramolecular medicinal chemistry
Gale, Philip A.; Davis, Jeffery T.; Quesada, RobertoPublished 2017-01-01New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...Open AccessArticle -
Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes
Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.Published 2017-12-01Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...Open AccessArticle -
Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
Rawling, Tristan; MacDermott-Opeskin, Hugh; Roseblade, Ariane; Pazderka, Curtis; Clarke, Callum; Bourget, Kirsi; Wu, Xin; Lewis, William; Noble, Benjamin; Gale, Philip A.; O'Mara, Megan L.; Cranfield, Charles; Murray, MichaelPublished 2020Respiring mitochondria establish a proton gradient across the mitochondrial inner membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial uncouplers collapse the proton gradient and disrupt ATP ...Open AccessArticle -
Binding and transport properties of a benzo[b]thiophene-based mono-(thio)urea library
Moiteiro, Cristina; Marques, Igor; Ryder, William G.; Cachatra, Vasco; Carvalho, Sílvia; Chen, Li-Jun; Goodfellow, Brian J.; Gale, Philip A.; Félix, VítorPublished 2021Using the chemical versatility of the benzo[ b ]thiophene motif, an extensive library of 24 (thio)urea receptors, with different binding properties and lipophilicities was prepared and included α,α-, α,β-, β,β-, β,γ-, α,γ-, ...Open AccessArticle -
Carbazole-based bis-ureas and thioureas as electroneutral anion transporters
Wang, Patrick; Wu, Xin; Gale, Philip A.Published 2021We report a series of easily accessible carbazole-based bis-ureas and thioureas as effective anion receptors and transporters. The compounds exhibit moderate Cl− binding affinity in wet DMSO and Cl− transport capabilities ...Open AccessArticle -
Crown ether-thiourea conjugates as ion transporters
Zhao, Zhixing; Tang, Bailing; Yan, Xiaosheng; Wu, Xin; Li, Zhao; Gale, Philip A.; Jiang, Yun-BaoPublished 2022Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic ...Open AccessArticle -
Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate
Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, LukePublished 2017-02-01Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...Open AccessArticle -
Delivering anion transporters to lipid bilayers in water
McNaughton, Daniel A.; To, Tsz Ying (Teresa); Hawkins, Bryson A.; Hibbs, David E.; Gale, Philip A.Published 2021Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre-incorporation.Open AccessArticle -
Design of Chiral Supramolecular Polymers Exhibiting a Negative Nonlinear Response
Chen, Xuan-Xuan; Lin, Xiao-Yan; Wu, Xin; Gale, Philip A.; Anslyn, Eric V.; Jiang, Yun-BaoPublished 2019-01-01Many synthetic and supramolecular chiral polymeric systems are known to exhibit the “majority rules effect” (MRE), a positive nonlinear response in which a small enantiomeric excess (ee) of the chiral building blocks leads ...Open AccessArticle -
Development of a library of thiophene-based drug-like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity
Vieira, Paulo; Miranda, Margarida Q.; Marques, Igor; Carvalho, Sílvia; Li-Jun, Chen; Howe, Ethan N.W.; Zhen, Carl; Leung, Claudia Y.; Spooner, Michael J.; Morgado, Bárbara; da Cruz e Silva, Odete A.B.; Moiteiro, Cristina; Gale, Philip A.; Félix, VítorPublished 2020-01-01The anion binding and transport properties of an extensive library of thiophene-based molecules are reported. Seventeen bis-urea positional isomers, with different binding conformations and lipophilicities, were synthetized ...Open AccessArticle -
Dissecting the chloride–nitrate anion transport assay
Yang, Yufeng; Wu, Xin; Busschaert, Nathalie; Furuta, Hiroyuki; Gale, Philip A.Published 2017-07-01A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals the ...Open AccessArticle -
Fatty Acid Fueled Transmembrane Chloride Transport
Howe, Ethan N.W.; Gale, Philip A.Published 2019-06-21Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump ...Open AccessArticle -
Fluorescent squaramides as anion receptors and transmembrane anion transporters
Bao, Xiaoping; Wu, Xin; Berry, Stuart N.; Howe, Ethan N.W.; Chang, Young-Tae; Gale, Philip A.Published 2018-01-01A series of squaramide-based anion transporters functionalised with the 1,8-naphthalimide fluorophore has been developed for improved ionophoric activity and fluorescent imaging in cells.Open AccessArticle
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