Browsing by author "Christie, M.J."
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Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers.
Wan, J; Bhola, R.F.; Jha, P; Brust, A; Mobil, M; Lewis, R.J.; Christie, M.J.; Alewood, P.F.Published 2016-05-01Peptide dendrimers are a novel class of macromolecules of emerging interest with the potential of delayed renal clearance due to their molecular size and enhanced activity due to the multivalency effect. In this work, an ...Open AccessArticle -
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain
Napier, I.A.; Klimis, H.; Rycroft, B.K.; Jin, A.H.; Alewood, P.F.; Motin, L.; Adams, D.J.; Christie, M.J.Published 2012-06-01The large diversity of peptides from venomous creatures with high affinity for molecules involved in the development and maintenance of neuropathic pain has led to a surge in venom-derived analgesic research. Some members ...Open AccessArticle -
Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively.
Enoksson, T.; Bertran-Gonzalez, J.; Christie, M.J.Published 2012-06-01Opioids are effective analgesic agents but serious adverse effects such as tolerance and withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal involves numerous brain regions and includes ...Open AccessArticle -
Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model
Jayamanne, A.; Jeong, H.J; Schroeder, C.I.; Lewis, R.J.; Christie, M.J.; Vaughan, C.W.Published 2013-09-01"BACKGROUND AND PURPOSE: Antagonists of the N-type voltage gated calcium channel (VGCC), Cav 2.2, have a potentially important role in the treatment of chronic neuropathic pain. ω-conotoxins, such MVIIA and CVID are effective ...Open AccessArticle -
Themed Section: Opioids New Pathways to Functional Selectivity
Christie, M.J.; Connor, M; Traynor, J.R.Published 2015-01-01"LINKED ARTICLES This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2"Open AccessArticle
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