Browsing by author "Buckley, Nicholas A."
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2-methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death.
Berling, I; Buckley, Nicholas A.; Downes, M.; Isbister, GK.Published 2015-04-15CASE REPORT: We report a fatal case of a 37 year old gentleman who ingested a MCPA/bromoxynil co-formulation herbicide. Although clinically well on initial examination, our patient declined dramatically over his 18 h ...Open AccessArticle -
Acute alcohol co-ingestion and hospital-treated deliberate self-poisoning; is there an effect on subsequent self-harm?
Borusso, LD; Buckley, Nicholas A.; Kirby, KA; Carter, G; Pilgrim, JL; Chitty, Kate M.Published 2018-03-01The aim of this study was to determine the relationship between alcohol co-ingestion in an index deliberate self-poisoning (DSP) episode with repeated DSP and subsequent suicide. A retrospective cohort study was conducted ...Open AccessArticle -
Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning could be a bad combination
Chan, Betty S.H.; Angela L., Chiew; Grainger, Sarah; Page, Colin B.; Gault, Alan; Mostafa, Ahmed; Roberts, Michael S.; Buckley, Nicholas A.; Isbister, Geoffrey K.Published 2018-01-30Open AccessArticle, Letter -
Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming
Silva, A.; Johnston, C.; Kuruppu, S.; Kneisz, D.; Maduwage, K.; Kleifeld, O.; Smith, A. I.; Siribaddana, S.; Buckley, Nicholas A.; Hodgson, W. C.; Isbister, G. K.Published 2016-12-02BACKGROUND: Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This ...Open AccessArticle -
Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.
Silva, A; Johnston, C; Kuruppu, S; Kneisz, D; Maduwage, K; Kleifeld O, O; Smith AI, AI; Siribaddana, S; Buckley, Nicholas A.; Hodgson, WC; Isbister, GKPublished 2016-12-02BACKGROUND: Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This ...Open AccessArticle -
Co-ingested alcohol and the timing of deliberate self-poisonings
Chitty, Kate M.; Kirby, Katharine; Osborne, Nicholas J.; Isbister, Geoffrey K.; Buckley, Nicholas A.Published 2018-08-01Objective: Investigating diurnal variation in the timing of suicidal behaviours offers opportunity to better understand its various proximal risk factors. Acute use of alcohol is a potent proximal risk factor for suicidal ...Open AccessArticle -
A decade of Australian methotrexate dosing errors
Cairns, R; Brown, J; Robinson, J; Lynch, AM; Wylie, C; Buckley, Nicholas A.Published 2016-06-06"OBJECTIVE: Accidental daily dosing of methotrexate can result in life-threatening toxicity. We investigated methotrexate dosing errors reported to the National Coronial Information System (NCIS), the Therapeutic Goods ...Open AccessArticle -
Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy
Pianta, Timothy J.; Pickering, John W.; Succar, Lena; Chin, Melvin; Davidson, Trent; Buckley, Nicholas A.; Mohamed, Fahim; Endre, Zoltan H.Published 2017-03-17BACKGROUND/AIMS: Plasma cystatin C (pCysC) may be superior to serum creatinine (sCr) as a surrogate of GFR. However, the performance of pCysC for diagnosing acute kidney injury (AKI) after cisplatin-based chemotherapy is ...Open AccessArticle -
Diagnosis-based and external cause-based criteria to identify adverse drug reactions in hospital ICD-coded data: application to an Australia population-based study
Du, W; Pearson, SA; Buckley, Nicholas A.; Day, C; Banks, EPublished 2017-04-27OBJECTIVES: External cause International Classification of Diseases (ICD) codes are commonly used to ascertain adverse drug reactions (ADRs) related to hospitalisation. We quantified ascertainment of ADR-related hospitalisation ...Open AccessArticle -
Discontinuities and disruptions in drug dosage guidelines for the paediatric population
Chitty, Kate M.; Chan, Bosco; Pulanco, Camille L.; Luu, Sonya; Egunsola, Oluwaseun; Buckley, Nicholas A.Published 2018-02-07AIMSThis study investigates paediatric drug dosage guidelines withthe aim of investigating their agreement with body surface area(BSA) scaling principles.METHODSA total of 454 drug dosage guidelines listed in the AMH-CDC ...Open AccessArticle -
Harmonizing post-market surveillance of prescription drug misuse: A systematic review of observational studies using routinely collected data (2000–2013)
Blanch, Bianca; Buckley, Nicholas A.; Mellish, Leigh; Dawson, Andrew H.; Haber, Paul S.; Pearson, Sallie-AnnePublished 2015-05-13Background Prescription drug misuse is a growing public health concern globally. Routinely collected data provides a valuable tool for quantifying prescription drug misuse. Objective To synthesize the global literature ...Open AccessArticle -
High lethality and minimal variation after acute self-poisoning with carbamate insecticides in Sri Lanka – implications for global suicide prevention
Lamb, Thomas; Selvarajah, Liza R.; Mohamed, Fahim; Jayamanne, Shaluka; Gawarammana, Indika; Mostafa, Ahmed; Buckley, Nicholas A.; Roberts, Michael S.; Eddleston, MichaelPublished 2016-06-02Highly hazardous organophosphorus (OP) insecticides are responsible for most pesticide poisoning deaths. As they are removed from agricultural practice, they are often replaced by carbamate insecticides of perceived lower ...Open AccessArticle -
Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance
Wunnapuk, Klintean; Liu, Xin; Gobe, Glenda C; Endre, Zoltan H; Peake, Philip W; Grice, Jeffrey E; Roberts, Michael S; Buckley, Nicholas A.Published 2014-03-21For improved early detection and assessment of severe acute kidney damage following accidental or intentional ingestion of the herbicide MCPA, we compared a panel of 14 novel kidney injury biomarkers with plasma creatinine. ...Open AccessArticle -
Kidney damage biomarkers detect acute kidney injury but only functional markers predict mortality after paraquat ingestion
Mohamed, Fahim; Buckley, Nicholas A.; Jayamanne, Shaluka; Pickering, John W.; Peake, Philip; Palangasinghe, Chathura; Wijerathna, Thilini; Ratnayake, Indira; Shihana, Fathima; Endre, Zoltan H.Published 2015-06-09Acute kidney injury (AKI) is common following paraquat ingestion. The diagnostic performance of injury biomarkers was investigated in serial blood and urine samples from patients from 5 Sri Lankan hospitals. Functional AKI ...Open AccessPreprint -
Kinetic Estimation of GFR Improves Prediction of Dialysis and Recovery after Kidney Transplantation
Pianta, T. J.; Endre, Z. H.; Pickering, J. W.; Buckley, Nicholas A.; Peake, P. W.Published 2015-05-04Background The early prediction of delayed graft function (DGF) would facilitate patient management after kidney transplantation. Methods In a single-centre retrospective analysis, we investigated kinetic estimated GFR ...Open AccessArticle -
Mechanisms underlying early rapid increases in creatinine in paraquat poisoning
Mohamed, F.; Endre, Z.; Jayamanne, S.; Pianta, T.; Peake, P.; Palangasinghe, C.; Chathuranga, U.; Jayasekera, K.; Wunnapuk, K.; Shihana, F.; Shahmy, S.; Buckley, Nicholas A.Published 2015-03-27Background Acute kidney injury (AKI) is common after severe paraquat poisoning and usually heralds a fatal outcome. The rapid large increases in serum creatinine (Cr) exceed that which can be explained by creatinine kinetics ...Open AccessArticle -
Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury.
Mohamed, F; Buckley, Nicholas A.; Pickering, JW; Wunnapuk, K; Dissanayake, S; Chathuranga, U; Gawarammana, I; Jayamanne, S; Endre, ZHPublished 2017-04-03BACKGROUND: Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for ...Open AccessArticle -
Neuromuscular Effects of Common Krait (Bungarus caeruleus) Envenoming in Sri Lanka
Silva, Anjana; Maduwage, Kalana; Sedgwick, Michael; Pilapitiya, Senaka; Weerawansa, Prasanna; Dahanayaka, Niroshana J.; Buckley, Nicholas A.; Johnston, Christopher; Siribaddana, Sisira; Isbister, Geoffrey K.Published 2016-02-01Objective We aimed to investigate neurophysiological and clinical effects of common krait envenoming, including the time course and treatment response. Methodology Patients with definite common krait (Bungarus caeruleus) ...Open AccessArticle -
Opioid use and harms associated with a sustained-release tapentadol formulation: a postmarketing study protocol
Peacock, Amy; Larance, Briony; Farrell, Michael; Cairns, Rose; Buckley, Nicholas A.; Degenhardt, LouisaPublished 2018-03-23Introduction It has been argued that tapentadol may pharmacologically have lower abuse potential than other pharmaceutical opioids currently available. However, there has been no comprehensive triangulation of data regarding ...Open AccessArticle -
Person-level changes in oxycodone use after the introduction of a tamper-resistant formulation in Australia
Schaffer, Andrea L; Buckley, Nicholas A.; Degenhardt, Louisa; Larance, Briony; Cairns, Rose; Dobbins, Timothy A; Pearson, Sallie-AnnePublished 2018-03-26ABSTRACT BACKGROUND: Australia introduced tamper-resistant controlled-release (CR) oxycodone in April 2014. We quantified the impact of the reformulation on dispensing, switching and poisonings. METHODS: We performed ...Article
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