Browsing by subject "zebrafish"
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High content analysis of granuloma histology and neutrophilic inflammation in adult zebrafish infected with Mycobacterium marinum
Published 2020-02-01Infection of zebrafish with natural pathogen Mycobacterium marinum is a useful surrogate for studying the human granulomatous inflammatory response to infection by Mycobacterium tuberculosis. The adaptive immune system of ...Open AccessArticle -
Investigating disease mechanisms and potential drug treatments in a transgenic zebrafish model of Machado-Joseph disease
Published 2019-04-08Machado-Joseph disease (MJD) is a neurodegenerative disease resulting in the loss of muscle control and coordination. This disease is caused by inheritance of the ATXN3 gene containing an expanded CAG trinucleotide repeat ...USyd AccessThesis -
Investigating the molecular mechanism of bioactive lipid inhibitors of GlyT2
Published 2022Lipid modulation of glycine transport has attracted significant attention as a potential analgesic pathway for neuropathic pain conditions. An array of bioactive lipids that potently inhibit GlyT2 have recently been developed ...USyd AccessThesis -
miRNA as biomarkers for identifying resilience to mycobacterial infection
Published 2021Pathogenic mycobacteria including Mycobacterium avium subsp. paratuberculosis (MAP), which is the causative agent of Johne’s Disease (JD), are able to manipulate host immune and transcriptomic pathways to cause chronic ...Open AccessThesis -
Transient responses to thermal change and underlying mechanisms
Published 2021Fluctuations in the thermal environment are ubiquitous and occur at different time scales. Organisms can respond via physiological adjustments that compensate for the negative effects of temperature change, and these ...Open AccessThesis