Browsing by subject "p21"
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ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair
Published 2008-06-25Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the ...Article -
Investigating the effects of novel iron-binding anti-cancer agents on p21Cip1/Waf1 regulation in cancer
Published 2016-12-31The cyclin dependent kinase (CDK) inhibitor, p21, is well known for its role in cell cycle arrest and tumour suppression [1]. However, recent studies suggest that, under certain conditions, p21 can promote proliferation, ...Thesis -
Understanding cisplatin resistance using cellular models
Published 2007-01-01Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of ...Article