Now showing items 1-5 of 5

    • Gadolinium(III) Complexes as Potential Theranostics 

      Hall, Andrew (University of Sydney School of Chemistry Faculty of Science, 2018-08-31)
      Neutron capture therapy and photon activation therapy are binary cancer treatments based on the release of high linear energy transfer particles from specific nuclides following neutron capture or X-ray photon excitation, ...
    • High mitochondrial accumulation of new gadolinium(III) agents within tumour cells 

      Morrison, Daniel E.; Aitken, Jade B.; de Jonge, Martin D.; Ioppolo, Joseph A.; Harris, Hugh H.; Rendina, Louis M. (Royal Society of Chemistry, 2014)
      The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The ...
    • Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents 

      Morrison, Daniel E.; Aitken, Jade B.; de Jonge, Martin D.; Issa, Fatiah; Harris, Hugh H.; Rendina, Louis M. (Wiley - V C H Verlag GmbH & Co. KGaA, 2014-10-16)
      A structure–activity relationship study of a library of novel bifunctional GdIII complexes covalently linked to arylphosphonium cations is reported. Such complexes have been designed for potential application in binary ...
    • Synthesis and DNA-binding studies of a dinuclear gadolinium(III)-platinum(II) complex 

      Fenton, Jacob M.; Busse, Madleen; Rendina, Louis M. (CSIRO Publishing, 2015-01-27)
      The synthesis and characterisation of a new dinuclear GdIII–PtII complex (1·PF6) containing a functionalised macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derivative linked to a PtII-terpy (terpy = 2,2′ ...
    • Tumor cell uptake and selectivity of gadolinium(III)-phosphonium complexes: The role of delocalisation at the phosphonium centre 

      Busse, Madleen; Windsor, Madeline S. A.; Tefay, Alexander J.; Kardashinsky, Mingyue; Fenton, Jacob M.; Morrison, Daniel E.; Harris, Hugh H.; Rendina, Louis M. (Elsevier, 2017-12)
      The synthesis of a series of bifunctional Gd(III) complexes 1–3 covalently bound to arylphosphonium cations possessing a varying degree of delocalisation at the phosphonium centre is presented. The influence of the degree ...