Browsing by subject "Ubiquitination"
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The discovery of specific small molecule inhibitors of p27 degradation through the targeting of SKP2
Published 2021Aims: There are two aims to this work: the in-silico screening component aimed to identify lead compounds which target Skp2-mediated degradation of the cyclin dependent kinase inhibitor p27, which regulates the cell cycle ...Thesis -
Genetic contribution to cytopathic effect in Vaccinia virus
Published 2014-06-02Vaccinia virus (VACV) infection induces cell migration, the formation of cytoplasmic extensions, actin polymerisation, cell rounding, detachment and lysis—changes collectively known as cytopathic effects (CPEs). Identification ...Thesis