Browsing by subject "T cells"
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Hepatic sinusoidal cells in liver immunology and ageing
Published 2005The liver has a key role both from a metabolic and an immunological viewpoint. It is involved in the metabolism, or degradation of different molecules absorbed by the intestine, including xenobiotics, drugs and lipids, the ...Open AccessThesis -
An investigation of relationships between cytokine-secreting T lymphocytes and transplantation outcome
Published 2002A major limitation to the success of transplantation is the immune interaction of the recipient and the graft tissue. When considering solid organ transplantation the major obstacle is overcoming rejection by the recipient ...Open AccessThesis -
Microarray studies of HIV-host interactions in relation to disease status and therapy effects
Published 2008HIV-host interactions can be interrogated at the level of both protein (proteome) and RNA (transcriptome). At protein level, previous studies have shown that expression levels of cell surface antigens such as CD38 and ...Open AccessThesis -
Murine adriamycin-induced nephropathy : the roles of cell-mediated immunity and CD4+ T-lymphocytes
Published 2000This thesis describes the establishment of a murine model of progressive nephropathy, and an examination of the role of CD4+ T cells in this model.Open AccessThesis -
Novel mechanisms of tolerance induction in the mouse
Published 2005In this study, we develop a novel strategy to deplete or “prune” alloreactive T cells defined on the basis of their proliferation following allo-stimulation. We use a skin graft model of CD4+ T cell mediated rejection ...Open AccessThesis -
Oxidative phenomena in T lymphocyte activation
Published 1997Murine lymph node cells (LNC) were used as model for the assessment of a role for reactive oxygen species (ROS) in T lymphocyte activation. When 2’7’- dichlorofluorescin (DCFHz) is oxidised it becomes the fluorescent ...Open AccessThesis -
Production and characterization of monoclonal antibodies to human activation and memory T cell antigens
Published 1990-01-01Open AccessThesis -
The regulation of peripheral T cell responses in TCR transgenic mice
Published 1997Transgenic mice expressing a T cell receptor specific for cytochrome C in association with I-Ek were employed to study the mechanisms regulating the decision between tolerance and immunity. Tolerance and immunity to the ...Open AccessThesis -
The Search for Replication-Competent HIV during Effective Therapy
Published 2020During HIV replication, the virus reverse transcribes its RNA genome into cDNA, which integrates into the human genome to facilitate viral protein production. These integrated genomes – the HIV provirus – remain within ...USyd AccessThesis -
Studies of the autoimmune reactions in the thyroid and peripheral blood of patients with Graves ophthalmopathy with an emphasis on the roles of the CD8+ T cells and the eye muscle antigen calsequestrin
Published 2018-02-16The mechanism for the association of autoimmunity in the thyroid and orbit in Graves ophthalmopathy (GO) is unclear but is most likely a result of autoimmune attack against a thyroid and orbital tissue shared antigen. In ...USyd AccessThesis -
Target antigen in chronic inflammatory demyelinating polyradiculoneuropathy
Published 2001The primary purposes of this study were to investigate humoral factors in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), to determine pathogenicity of the factors found, and to detect possible ...Open AccessThesis -
Tissue Resident T Cells In Human Disease
Published 2020Tissue resident memory T cells are a subset of memory T cells that reside in tissue permanently, without entering circulation. Their strategic location at sites of common pathogen entry or reinfection, provides a critical ...USyd AccessThesis -
A Transgenic Mouse Model Approach to Investigate the Interactions Between T Cells during the Course of an Immune Response
Published 2006-04-01The experiments described in this thesis document the development of two in vivo models, to investigate the effect of competition for peptide-MHC and factors independent of MHC on T cell proliferation, differentiation, ...Open AccessThesis