Browsing by subject "P2X7"
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Genetic, molecular, and neurobiological determinants of post-traumatic stress disorder-related behaviour in mice
Published 2020Post-traumatic stress disorder (PTSD), a debilitating mental health condition, can occur as a consequence of exposure to a traumatic, potentially life-threatening event or series of events. Debilitating intrusive thoughts, ...Thesis -
Novel P2X7 Receptor Ligands
Published 2019-06-20The P2X7 receptor (P2X7R) is a purinergic receptor that plays a central role in the inflammatory response. Activation of the P2X7R releases pro-inflammatory cytokines such as interleukin 1β (IL-1β), which have been shown ...Thesis -
Pharmacological evaluation of novel antagonists and a putative ligand at the purinergic P2X7 receptor
Published 2021Purinergic P2X7 receptors (P2X7R) are adenosine 5’-triphosphate (ATP)-gated ion channels highly expressed on microglia. P2X7R activation stimulates the release of proinflammatory cytokines such as interleukin-1β. Pre-clinically, ...Thesis