Browsing by subject "P-glycoprotein"
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Advancing ABC transporter biology: from cannabinoid interactions to neurobehavioural function
Published 2017-02-28Chapter 1 reviews the scientific literature and justifies the 3 main aims of this thesis. ATP-binding cassette (ABC) transporters are membrane bound efflux proteins located at several important biological barriers throughout ...USyd AccessThesis -
The Effect of The Tumor Microenvironment on Multi-Drug Resistance and the Assessment of Agents that Overcome this Effect
Published 2022Multidrug resistance (MDR) development is a major obstacle in the fight against cancer, primarily because of the over expression of ATP-binding cassette transporters (ABC transporters) such as P-glycoprotein (Pgp). Pgp ...USyd AccessThesis -
Function and regulation of P-glycoprotein: implications for amyloid-β export
Published 2022Alzheimer’s disease (AD) is a devastating neurodegenerative condition in which accumulation of amyloid-β (Aβ) peptides as plaques in the brain constitutes a hallmark feature. These peptides have been shown to cause impaired ...Open AccessThesis -
Overcoming the Dual Mechanism of Stress-Induced, Pgp-Mediated Drug Resistance using Novel Thiosemicarbazones
Published 2015-04-02Multi-drug resistance (MDR) is the principal mechanism by which many cancers develop resistance to chemotherapy drugs. It is the major factor responsible for the failure of many forms of chemotherapy. P-glycoprotein (Pgp) ...USyd AccessThesis