Now showing items 1-20 of 24

    • Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs† 

      Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P. (Royal Society of Chemistry, 2019-10)
      Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...
    • Anion receptor chemistry: Highlights from 2016 

      Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J. (Elsevier, 2018-02)
      This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.
    • Anion transport and supramolecular medicinal chemistry 

      Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto (Royal Society of Chemistry, 2017)
      New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...
    • Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes 

      Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P. (Royal Society of Chemistry, 2017-12)
      Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...
    • Confinement Assembly of ABC Triblock Terpolymers for the High-Yield Synthesis of Janus Nanorings 

      Steinhaus, Andrea; Chakroun, Ramzi; Müllner, Markus; Nghiem, Tai-Lam; Hildebrandt, Marcus; Groeschel, Andre H. (American Chemical Society (ACS), 2019-05-13)
      Block copolymers are versatile building blocks for the self-assembly of functional nanostructures in bulk and solution. While spheres, cylinders, and bilayer sheets are thermodynamically preferred shapes and frequently ...
    • Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate 

      Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, Luke (Royal Society of Chemistry, 2017-02)
      Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...
    • Dissecting the chloride–nitrate anion transport assay 

      Yang, Yufeng; Wu, Xin; Busschaert, Nathalie; Furuta, Hiroyuki; Gale, Philip A. (Royal Society of Chemistry, 2017-07)
      A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals ...
    • Fatty Acid Fueled Transmembrane Chloride Transport 

      Howe, Ethan N.W.; Gale, Philip A. (American Chemical Society, 2019-06-21)
      Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump uses ...
    • Fluorescent squaramides as anion receptors and transmembrane anion transporters 

      Bao, Xiaoping; Wu, Xin; Berry, Stuart N.; Howe, Ethan N.W.; Chang, Young-Tae; Gale, Philip A. (Royal Society of Chemistry, 2018-01)
      A series of squaramide-based anion transporters functionalised with the 1,8-naphthalimide fluorophore has been developed for improved ionophoric activity and fluorescent imaging in cells.
    • Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport 

      Spooner, Michael J.; Li, Hongyu; Marques, Igor; Costa, Pedro M.R.; Wu, Xin; Howe, Ethan N.W.; Busschaert, Nathalie; Moore, Stephen J.; Light, Mark E.; Sheppard, David N.; Gale, Philip A. (Royal Society of Chemistry, 2018)
      A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in cells ...
    • Fluorinated tripodal receptors for potentiometric chloride detection in biological fluids 

      Pankratova, Nadezda; Cuartero, Maria; Jowett, Laura A.; Howe, Ethan N.W.; Gale, Philip A.; Bakker, Eric; Crespo, Gastón A. (Elsevier, 2017-07)
      Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective ...
    • Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations 

      Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, Vítor (Royal Society of Chemistry, 2018)
      A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...
    • Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations 

      Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, Vítor (Royal Society of Chemistry, 2018-06-29)
      A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...
    • Hydroquinone-Based Anion Receptors for Redox-Switchable Chloride Binding 

      McNaughton, Daniel A.; Fu, Xiaochen; Lewis, William; D'Alessandro, Deanna M.; Gale, Philip A. (MDPI, 2019-07-11)
      A series of chloride receptors has been synthesized containing an amide hydrogen bonding site and a hydroquinone motif. It was anticipated that oxidation of the hydroquinone unit to quinone would greatly the diminish ...
    • Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents 

      Jowett, Laura A.; Howe, Ethan N.W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Pérez-Tomás, Ricardo; Gale, Philip A. (Springer Nature, 2017)
      Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...
    • Investigating the Influence of Steric Hindrance on Selective Anion Transport 

      Jowett, Laura A.; Ricci, Angela; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A. (MDPI, 2019-04-02)
      A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents ...
    • New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas 

      Jowett, Laura A.; Howe, Ethan N.W.; Wu, Xin; Busschaert, Nathalie; Gale, Philip A. (Wiley VCH, 2018-06-19)
      The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport ...
    • Real-Time Recording of the Cellular Effects of the Anion Transporter Prodigiosin 

      Cheung, Shane; Wu, Dan; Daly, Harrison C.; Busschaert, Nathalie; Morgunova, Marina; Simpson, Jeremy C.; Scholz, Dimitri; Gale, Philip A.; O'Shea, Donal F. (Cell Press, 2018-04-12)
      The unraveling of the cellular effects of anion transporters is key to their potential development as apoptosis-inducing or autophagy-disrupting therapeutics. Here, we conducted a systematic study of the cellular responses ...
    • Selective sensing of pyrophosphate in physiological media using zinc(II)dipicolylamino-functionalised peptides 

      Zwicker, Vincent E.; Long, Benjamin M.; Jolliffe, Katrina A. (Royal Society of Chemistry, 2015)
      A series of linear peptide based anion receptors, in which the distance between the bis[zinc(II)dipicolylamine] binding sites and the peptide backbone was varied systematically, was prepared and their anion binding ability ...
    • Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux 

      Zhang, Shaoyi; Wang, Yan; Xie, Wei; Howe, Ethan N.W.; Busschaert, Nathalie; Sauvat, Allan; Leduc, Marion; Gomes-da-Silva, Ligia C.; Chen, Guo; Martins, Isabelle; Deng, Xiaxing; Maiuri, Luigi; Kepp, Oliver; Soussi, Thierry; Gale, Philip A.; Zamzami, Naoufal; Kroemer, Guido (Springer Nature, 2019-02)
      Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate ...