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    • Pharmacological Evaluation of Cyanoguanidine P2X7 Receptor Antagonists 

      Jackson, Alexander Rodney (University of Sydney Sydney Medical School Discipline of Pharmacology, 2017-02-28)
      ABSTRACT BACKGROUND AND AIMS: The P2X7 receptor (P2X7R) is an ATP-gated, non-selective cation channel highly expressed on monocytes, macrophages and microglia. Prolonged activation of the P2X7R by ATP leads to cytolytic ...