Now showing items 1-3 of 3

    • A cross-study transcriptional analysis of Parkinson's disease 

      Sutherland, GT; Matigian, NA; Chalk, AM; Anderson, MJ; Silburn, PA; Mackay-Sim, A; Wells, CA; Mellick, GD (PloS one, 2009)
      The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer ...
    • Disease-specific, neurosphere-derived cells as models for brain disorders 

      Matigian, N; Abrahamsen, G; Sutharsan, R; Cook, AL; Vitale, AM; Nouwens, A; Bellette, B; An, J; Anderson, M; Beckhouse, AG; Bennebroek, M; Cecil, R; Chalk, AM; Cochrane, J; Fan, Y; Féron, F; McCurdy, R; McGrath, JJ; Murrell, W; Perry, C; Raju, J; Ravishankar, S; Silburn, PA; Sutherland, GT; Mahler, S; Mellick, GD; Wood, SA; Sue, CM; Wells, CA; Mackay-Sim, A (Disease models & mechanisms, 2010)
      There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new ...
    • NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease 

      Cook, AL; Vitale, AM; Ravishankar, S; Matigian, N; Sutherland, GT; Shan, J; Sutharsan, R; Perry, C; Silburn, PA; Mellick, GD; Whitelaw, ML; Wells, CA; Mackay-Sim, A; Wood, SA (PloS one, 2011)
      BACKGROUND: Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa ...