Now showing items 1-6 of 6

    • Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders 

      Leung, Sharon SY; Parumasivam, Thaigarajan; Gao, Fiona G; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim (Elsevier, 2017-04-15)
      This study aimed to develop inhalable powders containing phages active against antibiotic-resistant Pseudomonas aeruginosa for pulmonary delivery. A Pseudomonas phage, PEV2, was spray dried into powder matrices comprising ...
    • Jet nebulization of bacteriophages with different tail morphologies – structural effects 

      Leung, Sharon SY; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Carter, Elizabeth A; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim (Elsevier, 2019-01-10)
      It was previously demonstrated that the loss of infectivity of a myovirus PEV44 after jet nebulization was closely related to a change in bacteriophage (phage) structure. In this follow-up study, we further examined the ...
    • Nebulisation effects on structural stability of bacteriophage PEV44 

      Astudillo, Ariel; Leung, Sharon Shui Yee; Kutter, Elizabeth; Morales, Sandra; Britton, Warwick J; Chan, Hak-Kim (The Evergreen State College, Olympia, WA, USA, 2017-08-11)
      Nebulization being used for inhaled phage therapy can cause phage titer losses which may be the result of mechanical damage to the phages. This study aimed to determine effects of nebulization on the structural stability ...
    • Preparation of liposome-encapsulated bacteriophage PEV2 formulation 

      Leung, Sharon SY; Morales, Sandra; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim (The Evergreen State College, Olympia, WA, USA, 2017-08-11)
      Liposome-encapsulated (LE) phages have been reported to improve phage survival rate and biodistribution in body. Conventional thin film hydration followed by extrusion was generally employed to produce LE formulation. This ...
    • Production of Inhalable Bacteriophage Dry Powders 

      Leung, Sharon SY; Parumasivam, Thaigarajan; Carter, Elizabeth A; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim (RDD Online, 2017-04-28)
      Phage therapy is a possible alternative to conventional antibiotics to treat pulmonary infections caused by multidrug resistance (MDR) bacterial strains [1-4], due to its high specificity, low toxicity, capability of ...
    • Production of inhalation phage powders using spray freeze drying and spray drying techniques for treatment of respiratory infections 

      Leung, Sharon SY; Parumasivam, Thaigarajan; Gao, Fiona G; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim (Springer US, 2016-02-29)
      Purpose The potential of aerosol phage therapy for treating lung infections has been demonstrated in animal models and clinical studies. This work compared the performance of two dry powder formation techniques, spray ...