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    • TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator 

      Tsai, VWW; Macia, L; Johnen, H; Kuffner, T; Manadhar, R; Beck Jorgensen, S; Lee-Ng, KKM; Zhang, HP; Wu, L; Marquis, CP; Jiang, L; Husaini, Y; Lin, S; Herzog, H; Brown, DA; Sainsbury, Amanda; Breit, SN (PLoS ONE, 2013-02)
      The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of ...