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A Functional Approach to Ontology
Published 2021This thesis develops the functional approach to ontology, a conceptual-analytical approach that seeks to adjudicate ontological debates by analysing the functions of our concepts corresponding to the disputed entities. ...USyd AccessThesis -
Functional change in older adults ‘at risk’ of dementia
Published 2022At the present time, researchers have increasingly shifted their focus to earlier stages of dementia, such as subjective cognitive decline (SCD) and Mild Cognitive Impairment (MCI), to enable early diagnosis and/or ...USyd AccessThesis -
Functional Characterisation and Outcomes of Post Translational Modifications Driven by Fibroblast Activation Protein Enzyme Activity
Published 2015-08-25Fibroblast Activation Protein (FAP) is a cellXsurface anchored dimeric protease, closely related to Dipeptidyl Peptidase (DPP) 4. This atypical serine protease has both dipeptidyl peptidase and endopeptidase activities, ...USyd AccessThesis -
Functional Characterisation and Therapeutic Potential of the Zinc Finger Protein ZNF827
Published 2019-02-28The ends of linear eukaryotic chromosomes resemble double strand breaks, susceptible to the vigilant cellular DNA damage response machinery. Telomeres are specialised nucleoprotein structures found at the ends of human ...Open AccessThesis -
Functional Characterisation of C2H2-type Zinc Finger Proteins CTCF and ZNF512B
Published 2023The C2H2-zinc finger (ZF)-type family of proteins is the most abundant group of transcription factors involved in gene regulation. We showed this family is poorly-characterised as approximately 50% of members have little ...USyd AccessThesis -
Functional Characterisation of ELF2 in Haemopoietic Development
Published 2015-09-28ELF2 (E74-like factor 2), a member of the Ets family of transcription factors, has been reported to regulate genes important in B cell development, cell cycle progression, and angiogenesis. The two ELF2 isoforms, ELF2-A ...USyd AccessThesis -
Functional Characterisation of Fibroblast Activation Protein and Dipeptidyl Peptidase 9
Published 2011The dipeptidyl peptidase (DP) IV gene family consists of four atypical serine proteases, including DPIV, Fibroblast Activation Protein (FAP), DP8 and DP9, that belong to the prolyl oligopeptidase (POP) super—family. This ...Open AccessThesis -
Functional characterisation of the glutamine transporter ASCT2 and its potential as a molecular target in cancer therapy
Published 2021The Solute Carrier 1A (SLC1A) family comprises a group of membrane proteins that act as dual-function amino acid transporters and anion channels. It includes two major mammalian transport systems—the alanine serine cysteine ...USyd AccessThesis -
Functional characterisation of the Δ133p53 isoform and its mouse mimic Δ122p53
Published 2014-08-31p53 is a critical tumour suppressor. Recently several p53 isoforms have been discovered whose functions remain unclear. Evidence suggests that the Δ133p53 isoform may act as an antagonist to full length p53 (FLp53) and ...USyd AccessThesis -
Functional Characterization of Chickpea Nitrate Transporters
Published 2023Nitrate a major nitrogen source for plant growth has fluctuating soil availability and plants including legumes have to evolve efficient nitrate uptake systems to balance N requirements. Plant nitrate uptake systems respond ...Open AccessThesis -
Functional Cognition in Older Adults with Mild Cognitive Impairment and Mild Dementia: Validation of the Large Allen's Cognitive Level Screen
Published 2017-02-26Assessment of everyday function is essential to diagnose dementia and distinguish Mild Cognitive Impairment (MCI) from dementia. The term ‘functional cognition’ links the two constructs of function and cognition, integrating ...USyd AccessThesis -
Functional electrical stimulation and voluntary exercise to enhance cardiorespiratory responses to aerobic exercise in people with advanced multiple sclerosis
Published 2024Multiple sclerosis (MS) is a chronic, debilitating, inflammatory, and degenerative disease of the brain, spinal cord, and optic nerve. Some common symptoms include paralysis or paresis, reduced balance, and fatigue. These ...USyd AccessThesis -
Functional Gastrointestinal Disorders: relations between psychosocial factors, symptoms and sensorimotor disturbances
Published 1999-01-01Although a vast literature attests to the belief that psychosocial disturbance is an important component of functional gastrointestinal disorders (FGID), the relation of life stress, psychological distress and personality ...Open AccessThesis -
The functional implications of Termitomyces domestication on fungus-growing termite gut microbiomes
Published 2014-07-01Open AccessConference paper -
Functional lock-in and the problem of design transformation
Published 2017The act of introducing an innovation into an existing product by substituting or inserting new technologies is thought to be challenging due to the problem of integrating new components and sub-system architectures into ...Open AccessArticle -
A functional model for primary visual cortex
Published 2012-11-09Many neurons in mammalian primary visual cortex have properties such as sharp tuning for contour orientation, strong selectivity for motion direction, and insensitivity to stimulus polarity, that are not shared with their ...Open AccessThesis -
Functional Neuroanatomy of Morphine-Induced Abstinence, Tolerance, and Sensitisation
Published 2006-01-01The investigation into the relationship between neural plasticity in the rat forebrain associated with opiate-induced behaviours yielded two major results. The major finding of the functional neuroanatomy of acute morphine ...Open AccessThesis -
Functional neuroanatomy of tachykinins in brainstem autonomic regulation
Published 2006-08-01Little is known about the role that tachykinins, such as substance P and its receptor, the neurokinin-1 receptor, play in the generation of sympathetic nerve activity and the integration within the ventrolateral medulla ...Open AccessThesis -
Functional patterned coatings by thin polymer film dewetting
Published 2017-07-04An approach for the fabrication of functional polymer surface coatings is introduced, where micro-scale structure and surface functionality are obtained by means of self-assembly mechanisms. We illustrate two main applications ...Open AccessArticle -
Functional Polymer Templates for Metal Oxide Nanostructures
Published 2022Functional nanostructured metal oxides have attracted tremendous attention in the last several decades owing to their superior semiconducting, catalytic, and electronic properties over their bulk counterparts. While bulk ...USyd AccessThesis