Sydney Dental School

Oral Health Research Connect - May 2026

2026-06-01T03:38:10Z

Oral Health Research Connect - May 2026 Mancuso, Edoardo; Miletic, Vesna • Current trends in adhesive cementation: A research-based analysis of materials and clinical protocols- Dr Edoardo Mancuso The rapid evolution of restorative dentistry has introduced an extensive array of materials boasting superior mechanical and aesthetic properties. However, this progress necessitates a parallel advancement in adhesive systems and cementation protocols. With the market currently saturated by a plethora of luting options, clinicians frequently encounter challenges in selecting the most appropriate material for specific clinical scenarios. This presentation aims to provide a comprehensive, literature-based framework for the cementation of prosthodontic restorations, with a specific focus on substrate-driven selection. Recognizing that no universal "gold standard" protocol exists, as the properties of the abutment and the restorative material vary significantly, this session emphasizes the necessity of individualized clinical considerations for each case. Dr Edoardo Mancuso will analyze recent research and emerging materials, offering evidence-based guidelines to bridge the gap between laboratory data and chairside application. By synthesizing contemporary research with clinical technique, this session aims to guide clinicians in precise decision-making to enhance the predictability and success of adhesive restorations in routine practice. • Research priorities across academic career pathways in Sydney Dental School - Professor Vesna Miletic The OHRC invites Dr Vesna Miletic, recently re-appointed Director of Academic Career Development, for a discussion on how academics in Sydney Dental School can prioritise their research in the context of different academic careers (research, research-education, and education-focused) to meet and surpass expectations set by the University Academic Excellence Framework. The talk will be centred on how academics can set their goals, drawing on current scholarship and research opportunities aligned with the perspectives of the School and the University.

Oral Health Research Connect - April 2026

2026-04-27T22:10:19Z

Oral Health Research Connect - April 2026 Swinckels, Laura; Wrigley, Rachel The Oral Health Research Connect (OHRC) seminar series, organised by the Sydney Dental School, aims to foster a culture of research across the school, it’s partner Local Health Districts and other oral health stakeholders. The OHRC will achieve this through engagement and collaboration in a respectful, safe, constructive and positive discussion. It will be a research capacity and capability development opportunity for students, academics and clinicians. It will serve as a nexus for idea generation and research translation. Our Guest Speakers & Presentation Topic • How can AI support the early detection and prevention in oral healthcare, by reusing clinical data? - Laura Swinckels Laura will outline the research she conducted across her PhD about the use of Artificial Intelligence (AI) to support early detection and prevention in oral healthcare. She will show the value of preventive EHR data for early detection and prevention of oral diseases, and the clinical readiness of AI. Together, these stages form an overarching framework for AI in preventive oral healthcare, centred on reusing existing EHR data and the conditions required for clinical adoption. • Unlocking CAT2 Consultancy and Tender Opportunities: Supporting Research Impact Through Industry & Government Engagement - Rachel Wrigley This session offers a practical introduction to Category 2 and 3 funding; competitive tenders and fee-for-service consultancies, as a pathway to research impact and income diversification. Drawing on real Faculty case studies, we will cover the current oral health funding landscape, who the key commissioners are (government, ADA, industry, international bodies), how to assess and pursue opportunities, and the full support available through FMH Enterprise & Partnerships. Attendees will leave with a clear picture of where their expertise creates competitive opportunities and how to take the next step.

An In Vitro Investigation of Gas and Dye Leakage at the Implant–Abutment Junction Using Titanium and Cobalt Chrome-Based Abutments

2026-04-23T01:15:44Z

An In Vitro Investigation of Gas and Dye Leakage at the Implant–Abutment Junction Using Titanium and Cobalt Chrome-Based Abutments Bal, Amylia Kesha; Walton, Terry Richard; Kruse, Hedi Verena; Howes, Dale Geoffrey Abstract The lack of integrity at the implant–abutment junction (IAJ) contributes to problems such as micromovements and microbial colonisation. This study aimed to (1) design a protocol for assessing microleakage at the IAJ using chromophore analysis not previously reported for this specific application, (2) compare gas and dye leakage between titanium (Ti) and cobalt chrome (CoCr) abutments, and (3) assess the effect of gold (Au) gilding on sealing. Forty abutments were divided into five groups: milled Ti (MTi); cast CoCr (CCoCr); milled CoCr (MCoCr); cast CoCr with Au gilding (CCoCrG); and milled CoCr with Au gilding (MCoCrG). Samples were subjected to internal pressure within a gas and dye reservoir. Chromophore analysis via UV-Vis spectrometer was used to calculate crystal violet leakage concentrations. Scanning electron microscopy (SEM) revealed close adaptation in the MTi and MCoCr groups, contrasting with irregularities in the CCoCr groups. Correspondingly, gas leakage and dye leakage were most prevalent in the CCoCr group. Fisher exact test demonstrated a statistically significant difference (p = 0.026) between the MCoCr and CCoCr abutments. While CCoCr exhibited the highest failure rate (62.5%), Au gilding demonstrated a trend toward reduced leakage (25% failure rate), though this did not reach statistical significance (p = 0.315). This chromophore analysis represents a viable and objective assessment of IAJ integrity.

Noel Martin Visiting Chair Seminar-19 March

2026-03-31T00:21:24Z

Noel Martin Visiting Chair Seminar-19 March Benzian, Habib Presentation Topic: Realigning Research with Population Impact: Global Strategies- Prof Habib Benzian This presentation will examine how academic institutions can respond to these global recommendations by aligning curricula, research strategy, and funding priorities with the broader NCD agenda. Oral health is not a peripheral specialty issue, but a test case for whether research ecosystems are prepared to translate knowledge into equitable population impact. These recommendations carry significant implications for dental and medical education and research. They challenge universities to rebalance portfolios toward population health, prevention, and system design; to strengthen interdisciplinary collaboration across dentistry, medicine, and public health; and to build capacity in implementation science and health policy analysis. They also raise questions about funding structures that continue to privilege biomedical discovery over delivery and system performance. Oral diseases are among the most prevalent noncommunicable diseases, yet oral health research remains fragmented and often disconnected from mainstream NCD agendas. The WHO Global Oral Health Action Plan sets out clear research and monitoring priorities, calling for stronger surveillance systems, implementation research, health systems evidence, and equity focused approaches that move beyond narrow clinical paradigms.

My Experience in Medical–Dental Collaboration at Okayama University

2026-04-29T00:40:29Z

My Experience in Medical–Dental Collaboration at Okayama University Yamanaka, Raiko Dr Yamanaka-Kohno is a Senior Assistant Professor in the Department of Preventive Dentistry at Okayama University, Japan. She is a qualified dentist and holds a PhD in Dentistry from Okayama University Graduate School. She has over 15 years of experience in multidisciplinary clinical practice, education, and research at Okayama University Hospital. Dr Yamanaka-Kohno and Associate Professor Akhter previously worked at Okayama University during overlapping periods, and this visit provides an opportunity to renew academic connections and explore potential areas of collaboration. Her research focuses on perioperative oral management and its impact on systemic outcomes in cancer patients. She has published several peer-reviewed papers as first and corresponding authors in leading international journals, including Scientific Reports (IF 3.8; Top 10% journal according to Scopus), Nutrients (IF 5.0; Q1 journal), and Esophagus (IF 3.1; Q1 journal). Her research outcomes have been widely introduced in Japan, including coverage by multiple national newspapers, and were also introduced in a post on Nature Japan’s X account. In recognition of her contributions, she received three academic society awards between 2025 and 2026, including awards in the fields of oral health and medical rehabilitation. Dr Yamanaka-Kohno is currently supported by the Japanese government’s “Initiative for Realizing Diversity in the Research Environment” program administered by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and by a grant from the Japan Society for the Promotion of Science (JSPS) to investigate the systemic oral microbiome in perioperative colorectal cancer patients. During her visit, she is keen to explore opportunities for future research collaboration and educational exchange between the Faculty of Medicine and Health, University of Sydney and Okayama University.

Oral Health Research Connect - December 2025 - Guest Speakers: Prof Yin Xiao and Dr Eduardo Delamare

2025-12-08T10:02:03Z

Oral Health Research Connect - December 2025 - Guest Speakers: Prof Yin Xiao and Dr Eduardo Delamare Xiao, Yin; Delamare, Eduardo The Oral Health Research Connect (OHRC) seminar series, organised by the Sydney Dental School, aims to foster a culture of research across the school, it’s partner Local Health Districts and other oral health stakeholders. The OHRC will achieve this through engagement and collaboration in a respectful, safe, constructive and positive discussion. It will be a research capacity and capability development opportunity for students, academics and clinicians. It will serve as a nexus for idea generation and research translation. Our Guest Speakers & Presentation Topic • Regenerative Dentistry: Opportunities and Challenges- Prof Yin Xiao Regenerative dentistry is an emerging field that applies principles of tissue engineering, stem cell biology, biomaterials science, and molecular biology to restore the structure and function of dental and oral tissues lost to disease, trauma, or congenital anomalies. It aims to go beyond traditional restorative approaches by promoting biological regeneration rather than synthetic replacement. While regenerative dentistry holds great promise, challenges remain in translating benchside innovations to routine clinical practice. These include Ensuring long-term safety and efficacy of stem cell-based therapies; Standardizing manufacturing of scaffolds and biologics under GMP conditions; Navigating regulatory pathways for advanced therapeutic medicinal products (ATMPs; Achieving predictable clinical outcomes in complex oral environments. Despite these challenges, regenerative dentistry represents the future of oral health care, with the potential to revolutionize the management of dental diseases by enabling biologically driven restoration and tissue renewal. • Applications of Rule-Based Reasoning Strategies to Address Limitations of AI Systems in DMFR-Dr Eduardo Delamare Dr Delamare will present a segment of his PhD research discussing innovative strategies to overcome the interpretability and explainability limitations of AI-based tools when used in diagnostic tasks across dental applications. By incorporating classic surface mapping tools into AI-based segmentations, these systems intend to offer higher reliability and facilitate adoption in clinical practice. The discussion will delve into specific methodologies that integrate traditional diagnostic techniques with cutting-edge AI algorithms to enhance accuracy and clinician confidence. Participants will gain insights into case studies demonstrating the practical application of these strategies, highlighting improvements in diagnostic precision. Furthermore, the session will address challenges faced during implementation and provide guidelines for effective integration of these AI-enhanced tools into routine dental workflows, aiming to bridge the gap between technology development and real-world clinical utility.

Oral Health Research Connect - November 2025: Guest Speakers Dr Edward Waters & Associate Professor Delyse Leadbeatter

2025-11-06T23:45:28Z

Oral Health Research Connect - November 2025: Guest Speakers Dr Edward Waters & Associate Professor Delyse Leadbeatter Waters, Edward; Leadbeatter, Delyse The Oral Health Research Connect (OHRC) seminar series, organised by the Sydney Dental School, aims to foster a culture of research across the school, it’s partner Local Health Districts and other oral health stakeholders. The OHRC will achieve this through engagement and collaboration in a respectful, safe, constructive and positive discussion. It will be a research capacity and capability development opportunity for students, academics and clinicians. It will serve as a nexus for idea generation and research translation. Our Guest Speakers & Presentation Topic • What can population health researchers learn from educational research?- Dr Edward Waters His talk focuses on how his mathematical training influences his educational research, and what education research can teach population health researchers about planning studies and asking the right questions of themselves. • What can population health researchers learn from educational research?- A/Prof Delyse Leadbeatter Her talk continues the theme of researcher reflexivity and transformation and focuses on what strong researcher reflexivity can look like and what putting reflexivity into practice means, including the benefits of developing methodological self-consciousness.

Oral Health Research Connect - September 2025: Guest Speaker Dr Antonin Tichy and Professor Vesna Miletic

2025-09-11T04:47:36Z

Oral Health Research Connect - September 2025: Guest Speaker Dr Antonin Tichy and Professor Vesna Miletic Tichy, Antonin; Miletic, Vesna The Future and Challenges of AI in Dentistry- Dr Anotonin Tichy Big data and artificial intelligence (AI) have transformative potential to enhance clinical decision-making, personalize treatment, and improve outcomes in dentistry. This presentation explores persisting major challenges, including data quality, lack of model validation and explainability, practical obstacles to clinical implementation of AI tools, as well as governance and ethical considerations. This is followed by future trajectories, such as improving data quality through interoperability, federated learning, or multi-modal AI. If successful, AI tools could significantly also significantly contribute not only to clinical-decision-making and predictive dentistry, but also improving care via practice management and teledentistry. • Leading Change in Dentistry: Research and Innovation in Materials and Education-Professor Vesna Miletic This presentation outlines research I have been doing in dental materials and, more recently, dental education. I lead interdisciplinary projects and teams exploring both experimental and commercial dental materials, mainly resin-based composites, adhesives, bioactive restorative materials and endodontic sealers, examining their physical and chemical properties and aiming to translate laboratory findings into clinical practice. Alongside biomaterials research, my team develops innovative teaching methods to enhance student manual dexterity and clinical skills in tooth conservation. Recent projects involve smart sensor technologies for dental training, improving the simulation of real-world procedures and AI-driven deep learning in dental education. This talk will also highlight future directions to advance dental education and dental materials for clinical application.

Oral Health Research Connect - August 2025: Guest Speaker - Associate Professor James Tsoi

2025-08-06T23:27:33Z

Oral Health Research Connect - August 2025: Guest Speaker - Associate Professor James Tsoi Tsoi, James Topic: 3D-PAIR (Printing/AI/Robotics) in Dentistry-Prof James Tsoi Technologies are changing so fast, and the dental landscape is also leveraged and transformed from traditional to digital and then to autonomous dentistry. This lecture will be focusing on various (comparatively) new 3D-printing, AI and robotics (3D-PAIR) research and technologies from HKU Dental Materials Science. By utilizing 3D-PAIR as a tech-core and "mix & match" with new materials, designs and treatment modalities, we aim at creating new values for dentists, dental manufacturers, and patients/the general public.

Oral Health Research Connect - July 2025 - Guest Speaker: Dr Padma Gadiyar & Dr Shalinie King

2025-07-07T21:47:00Z

Oral Health Research Connect - July 2025 - Guest Speaker: Dr Padma Gadiyar & Dr Shalinie King Gadiyar, Padma; King, Shalinie AI-Driven Innovation in Oral Health: Advancing Early Assessment, Access, and Triage Pathways - Dr Padma Gadiyar Dr Gadiyar will introduce Smilo.ai - an AI-powered digital health platform designed to transform dental care through virtual checkups, smile simulations, remote monitoring, and a 24/7 AI voice receptionist. She will walk through the core product features, the communities Smilo.ai serves, and the impact it has made so far. Dr Gadiyar will also share the team's goals for the future and explore opportunities for collaboration with the University of Sydney -particularly in clinical validation and co-developing innovative solutions to improve patient care, reduce waiting times, and enhance the efficiency of the oral healthcare system. Oral Health Research at WARC - Dr Shalinie King The Westmead Applied Research Centre (WARC) was established by the University of Sydney in collaboration with the Western Sydney Local Health District to create and apply innovation to addressing chronic health conditions. WARC brings together multidisciplinary experts to co-design, evaluate and translate innovative solutions into healthcare and prevention. It partners with industry, government, not-for-profit organisations. As programme lead for oral health research at WARC Dr King will provide an overview of the oral health related research activity at WARC and discuss opportunities for engagement and collaboration with the Dental School.

Oral Health Research Connect - June 2025: Guest Speaker - Dr Morgan James & Dr Katharina Rabelo

2025-06-06T00:41:01Z

Oral Health Research Connect - June 2025: Guest Speaker - Dr Morgan James & Dr Katharina Rabelo James, Morgan; Rabelo, Katharina Translational Projects in Pain Management - Dr Morgan James: Dr James will highlight two translational projects in pain management. The first describes the development of a chemogenetic strategy to selectively reduce activity in trigeminal ganglion neurons in an animal model of trigeminal neuralgia—proof-of-concept work that is now guiding clinical translation of this technology. The second outlines the structure-based design and preclinical characterization of a novel sigma-1 receptor antagonist, developed as a potential adjunct to enhance opioid-based pain therapies. AI-Driven Deep Learning in Dental Radiology: Advancing Education, Clinical Training, and Research - Dr Katharina Rabelo: Dr Rabelo will present a segment of her PhD research focused on leveraging AI to enhance dental radiology education and clinical training, while also advancing AI research within the field. She will share the results of the evaluation of an automated deep-learning system designed to detect positioning errors in bitewing radiographs. This technology supports AI-driven educational resources, assists clinicians in assessing the diagnostic value of each image before interpretation, and advances AI research by improving the management of heterogeneous datasets.

Oral Health Research Connect - May 2025: Guest Speaker - Dr Niamh Chapman & Associate Professor Rahena Akhter

2025-05-08T06:03:48Z

Oral Health Research Connect - May 2025: Guest Speaker - Dr Niamh Chapman & Associate Professor Rahena Akhter Chapman, Niamh; Akhter, Rahena Our Guest Speakers & Presentation Topic • Person-centred approaches to the management of blood pressure - Dr Niamh Chapman It will cover strategies for effective patient education, integration of blood pressure measurement into existing care pathways and team-based care approaches to hypertension management. • Oral Health during Pregnancy and Miscarriage: What You Need to Know - Associate Professor Rahena Akhter It will cover the impact on oral heath due to hormonal changes during Pregnancy and Miscarriage, dental care considerations, oral health education, treatment considerations and current research evidence to discuss this relationship.

Mind the Gap in antibiotic prescribing by dentists in the U.S

2025-04-16T01:26:06Z

Mind the Gap in antibiotic prescribing by dentists in the U.S Suda, Kate J Dentists prescribe 1 out of every 10 antibiotic prescriptions in the U.S., exceeding prescribing rates by dentists in other countries. In the U.S. 80% of antibiotics prescribed by dentists are inconsistent with clinical treatment guidelines. New guidelines changes, data associating adverse events with dental antibiotics, and increasing community-associated resistant infections have led to an increased interest to improve antibiotic prescribing by dentists.

Effectiveness of oral health promotion interventions: an evidence check rapid review brokered by the Sax Institute and commissioned by Dental Health Services Victoria for the Victorian Department of Health

2025-02-27T03:37:54Z

Effectiveness of oral health promotion interventions: an evidence check rapid review brokered by the Sax Institute and commissioned by Dental Health Services Victoria for the Victorian Department of Health Rana, Kritika; Ekanayake, Kanchana; Chimoriya, Ritesh; Palu, Elizabeth; Do, Loc G.; Silva, Mihiri; Tadakamadla, Santosh; Bhole, Sameer; Leshargie, Cheru Tesema; Wen, Li Ming; Ha, Diep; Arora, Amit The aim of this Evidence Check rapid review—funded by the Victorian Department of Health and commissioned by the Dental Health Services Victoria—is to synthesise the evidence for the effectiveness of oral health promotion interventions in the Australian population. It contains 46 reviews published between 2012 and 2021 that included studies conducted in Australia and other countries and jurisdictions with comparable health systems to Victoria and Australia, i.e. the UK, New Zealand, Canada and the US.

Harnessing theory and epidemiological methods to address oral health inequalities

2024-08-07T05:32:41Z

Harnessing theory and epidemiological methods to address oral health inequalities Singh, Dr Ankur Oral Health Research Connect (OHRC) presentation conducted 1 August 2024, by Dr Ankur Singh titled "Harnessing theory and epidemiological methods to address oral health inequalities".

Findings and Future Directions from a Smoking Cessation Trial Utilizing a Clinical Decision Support Tool

2026-04-29T00:40:28Z

Findings and Future Directions from a Smoking Cessation Trial Utilizing a Clinical Decision Support Tool Rindal, D. Brad; Kottke, Thomas E.; Jurkovich, Mark W.; Asche, Stephen E.; Enstad, Chris J.; Truitt, Anjali R.; Ziegenfuss, Jeanette Y.; Romito, Laura M.; Thyvalikakath, Thankam P.; O'Donnell, Jean; Spallek, Heiko Background Tobacco smoking is the leading cause of disease, death, and disability in the United States. Dental practitioners are advised to provide evidence-based smoking cessation interventions to their patients, yet dental practitioners frequently fail to deliver brief smoking cessation advice. Objectives To test whether giving dental practitioners a clinical decisions support (CDS) system embedded in their electronic dental record would increase the rate at which patients who smoke 1) report receiving a brief intervention or referral to treatment during a recent dental visit, 2) taking action related to smoking cessation within 7 days of visit, and 3) stop smoking for one day or more or reduce the amount smoked by 50% within 6 months. Methods Two-group, parallel arm, cluster-randomized trial. From March through December 2019, 15 non-academic primary care dental clinics were randomized via covariate adaptive randomization to either a usual care arm or the CDS arm. Adult smokers completed an initial telephone survey within 7 days of their visit and another survey after 6 months. Results Forty-three patients from 5 CDS and 13 patients from 2 usual care clinics completed the 7-day survey. While the proportion of patients who reported receipt of a brief intervention or referral to treatment was significantly greater in the CDS arm than the usual care arm (84.3% versus 58.6%; p = 0.005), the differences in percentage of patients who took any action related to smoking cessation within 7 days (44.4% versus 22.3%; p= 0.077), or stopped smoking for one day or more and/or reduced amount smoked by 50% within 6 months (63.1% versus 46.2%; p = 0.405) were large but not statistically significant. Conclusions Despite interruption by Covid-19, these results demonstrate a promising approach to assist dental practitioners in providing their patients with smoking cessation screening, brief intervention and referral to treatment.

Dental student oral surgery training - Comparing the impact of COVID-19 and cohort sizes

2026-04-29T00:40:25Z

Dental student oral surgery training - Comparing the impact of COVID-19 and cohort sizes Thorpe, Andrew Raymond Darren Scott; Hsu, Joyce; Carter, Eric Francis; Ullah, Mafaz; Cox, Stephen Clive INTRODUCTION: The response to the COVID-19 pandemic potentially reduced the clinical experience and academic education of dental trainees through reduced supervised clinical sessions. Graduating dental students, future employers and regulators may be concerned over the level of clinical experience of graduates trained within the COVID-19 pandemic. The purpose of this study was to try and document the evidence for, and significance of, this impact. MATERIALS AND METHODS: From dental student data in the 2017, 2018, 2019 and 2020 cohorts attending the University of Sydney, Australia, the number of dental extractions and adjunct oral surgery procedures, as well as final end-of-year examination results, was recorded. Results were compared to determine whether differences in experience and final academic achievement existed between these cohorts. RESULTS: The smallest student cohort, 2017, demonstrated greater clinical experience than the 2018, 2019 and 2020 cohorts. The 2020 COVID-19-affected cohort demonstrated no statistically significant reduction in clinical experience in all measured clinical procedures when compared to the 2018 and 2019 cohorts. The decrease in city teaching hospital clinical experience was compensated by an increase in rural placements. The 2020 cohort achieved the lowest academic results, and this was statistically significant. CONCLUSION: The oral surgery clinical experience of the 2020 dental cohort at the University of Sydney was comparable to prior cohorts. Rural clinics were able to compensate for COVID-19 interruptions to clinical training. The number of students in a cohort, if all other variables remain constant, appeared to affect clinical exposure to a greater extent than COVID-19.

The role of operative dentistry in the aetiology of periodontal disease

2026-04-29T00:40:25Z

The role of operative dentistry in the aetiology of periodontal disease Walker, Geoffrey Michael Every dentist has seen damage to the gingiva caused by faulty, roughly finished and poorly contoured restorations, and every periodontist is aware of the important role which can be played by operative dentistry in the aetiology of periodontal disease. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

An In-Vitro Investigation Of The Fit Of Anterior Porcelain And Porcelain-Metal Full-Veneer Restorations

2026-04-29T00:40:30Z

An In-Vitro Investigation Of The Fit Of Anterior Porcelain And Porcelain-Metal Full-Veneer Restorations Walton, Terry Richard When C.H. Land introduced the porcelain jacket crown in 1902, it enabled the application of the desirable aesthetic qualities of porcelain to be applied to full veneer dental restorations. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

The response of bone to orthodontic force.

2026-04-29T00:40:30Z

The response of bone to orthodontic force. Walsh, Paul Joseph Bone is a living cellular part of the animal organism. It is continually changing size and form and substance from the foetal period throughout the whole of life. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

A Study Of Inferior Dental Nerve Regeneration Following Traumatic Injury

2026-04-29T00:40:31Z

A Study Of Inferior Dental Nerve Regeneration Following Traumatic Injury Vadiveloo, V. K The consequences of damage to sensory nerve fibres depend on the nature, site and severity of that injury. Rupture or contusion of the inferior dental nerve invariably produces altered sensations and the symptoms which accompany such an 'injury are generally those of anaesthesia or paraesthesia in the area of distribution of the mental nerve i.e., the lower lip and chin. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

Proximal stripping and enamel surface roughness

2026-04-29T00:40:29Z

Proximal stripping and enamel surface roughness Vickers, Daniel Ian Proximal stripping, according to Peck and Peck (1972A), "is a clinical procedure involving the reduction, anatomic recontouring, and protection of the mesial and/or distal enamel surfaces of a permanent tooth”. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

Pregnant women as an effective target for preventive periodontal intervention

2026-04-29T00:40:29Z

Pregnant women as an effective target for preventive periodontal intervention Wong-Lee, Joyce Tzu Kia Gingivitis and periodontitis are periodontal diseases common to all populations. Gingivitis is a non-specific infection by plaque bacteria while periodontitis is a group of diseases resulting from the interplay of different host responses to specific groups of plaque bacteria. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

The effect of COVID-19 pandemic on final year dental students’ self-confidence level in performing clinical procedures

2026-04-29T00:40:25Z

The effect of COVID-19 pandemic on final year dental students’ self-confidence level in performing clinical procedures Ilić, Jugoslav; Radović, Katarina; Savić-Stanković, Tatjana; Popovac, Aleksandra; Miletić, Vesna; Lemić, Aleksandra Milić "BACKGROUND: The outbreak of COVID-19 pandemic in 2020 has dramatically changed teaching approach in dental schools due to the switch to distance learning and the lack of practice training in direct contact with patients with possible impact on clinical skills of students. The aim of the study was to assess the level of the 2020 final year dental students' self-confidence in performing different dental procedures through specially designed questionnaire and compare it to self-confidence of the 2019 final year students. MATERIALS AND METHODS: An anonymous questionnaire consisting of 40 questions regarding self-confidence level in performing 40 different dental procedures and based on five points Likert-like scale was distributed during November 2020 to final year dental students whose studies were disrupted by the COVID-19 pandemic lockdown in one semester. The study group comprised their answers. The comparison was done with the control group that consisted of students' answers on the same questionnaire from previous 2019 year conducted as a part of regular internal educational evaluation. RESULTS: Response rate was 74.2% in study group and 89.3% in control group. Mean level of self-confidence reported by 115 students in study group was significantly lower than that reported by 100 students in control group (3.28±1.08 vs. 3.58±0.88, respectively) and the distribution of self-confidence scores were different in observed groups. Graduates from study group felt less confident than those from control in 8 clinical skills. CONCLUSION: Abrupt changes in teaching modalities caused by COVID-19 pandemic had significant impact on final year dental students' self-confidence indicating additional educational needs in postgraduate period."

Glass Ionomer Cements: Strength, Film Thickness And Sem Investigation

2026-04-29T00:36:54Z

Glass Ionomer Cements: Strength, Film Thickness And Sem Investigation Wong, Theresa Cheng Chuin The strength (compressive and tensile), film thickness, surface obtained with various clinical finishing techniques, and the particle size of seven commercial glass ionomer cements were investigated. Three restorative cements and four luting cements were examined. Three aspects of the experimental method were also investigated: the dispensing of the powder and liquid, specimen preparation for scanning electron microscopy (SEM), and the technique for examining the glass particle size of the cements in the SEM. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Post orthodontic treatment occlusions objectives and simulation of treatment : a study of centric stops

2026-04-29T00:40:25Z

Post orthodontic treatment occlusions objectives and simulation of treatment : a study of centric stops Wigmore, Tim Aesthetics is often the main and occasionally the only criteria by which orthodontic treatment is judged. The literature has many references concerning the ideal positions of teeth, however little importance is given to the tooth contacts that eventuate. It is assumed on a number of occasions that settling will provide the best possible fit. The aim of this thesis is to simulate orthodontic treatment on hypothetical patients and evaluate the tooth contacts which result from this treatment. Stylised tooth contacts have been produced for intact dentitions but in spite of an extensive search of the literature no patterns for extraction cases were found. The experiment, therefore, was to use "normal" teeth in wax malocclusions representing Class I, Class H Div 1, Class II Div 2 and Class III. Where it was indicated these were treated with extractions of premoiar teeth. It was considered that the different mechanics and torque values of the anterior brackets may have dissimilar affects on the resultant occlusions. If this was the case it would be manifest in the resultant tooth contacts. Quantity and site of tooth contact was noted, quality was difficuit to assess as one may move teeth to where one believes they belong but nature will place them where they best adapt to the needs of the stomatognathic system. This obviously could not be considered using an articulator and wax models. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

An Evaluation Of A Eutectic Topical Anaesthetic (EMLA Cream 5%)

2026-04-29T00:36:53Z

An Evaluation Of A Eutectic Topical Anaesthetic (EMLA Cream 5%) Vickers, Edward Russell Eutectic Mixture of Local Anaethetics cream 5% (EMLA) is a 1:1 oil/water emulsion of a eutectic mixture of lignocaine 2.5% and prilocaine 2.5%. It is a new topical anaesthetic approved for medical purposes. Its medical indications include reducing the pain experienced during venous cannulation, the harvesting of skin grafts and the removal of genital warts. A series of studies was carried out to investigate the efficacy and safety of EMLA for dental applications. Study 1 compared EMLA, NUM and Xylocaine 5% topical anaesthetics with placebo, for their efficacy in reducing the pain experienced during needle insertion in the oral mucosa. Results from study 1 showed that EMLA was the most effective agent when compared with placebo. Study 2 compared EMLA with Xylocaine 5% but no significant difference was found. Study 3 examined the depth of anaesthesia from longer application times of EMLA, Xylocaine 10% and placebo by electrical pulp testing. ReSults showed that EMLA was effective in blocking the response to the maximum stimulus of the pulp tester (300 volts) in 92% of subjects tested. Study 4 evaluated the plasma concentratio ns of prilocaine and lignocaine from 8 mL of EMLA applied to the oral mucosa. Analysis of venous blood samples by high pressure liquid chromatogr aphy showed the maximum plasma concentratio n for prilocaine to be 223 ng/mL and for lignocaine to be 418 ng/mL. Both concentrations were well below known toxic levels for the drugs. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Lateral Cephalometric Study Of Indonesian Class II Division 1 Malocclusion

2026-04-29T00:40:30Z

Lateral Cephalometric Study Of Indonesian Class II Division 1 Malocclusion Wihardja, Rosy Cephalometric radiography has been accepted worldwide as a powerful tool to study craniofacial growth, to diagnose deviations of an individual from population norms, and to plan orthodontic treatment and assess its progress and results, although it is not free from errors. Chung, Runck, Bilben, Kau (1986) state that racial differences in craniofacial morphology are well recognized. Their study shows that the Oriental people including Japanese, Chinese, and Koreans, characterised by larger lateral dimensions Caucasians, as measured by bizygomatic diameter, bigonial diameter, and head breadth. The anteroposterior dimension as measured by head length shows the opposite trend. It is not known what genetic forces are responsible for maintaining these racial differences. As a result, and as also proved by many cephalometric studies on different races, different race gives different appearance cephalometrically too. The aim of this study is to find the pattern of dyscrepancy in Class II division 1 malocclusion in Indonesian people. The Indonesian is the outcome of the intermingling of many ancient races. If the "normal" occlusion of Asian people appears with certain unique cephalometric characteristics when comparison is made with the Caucasians norms, it seems logical to assume that the "abnormal" occlusion will show unique characteristics as well. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

The linking of a Brånemark implant to a natural tooth

2026-04-29T00:40:32Z

The linking of a Brånemark implant to a natural tooth Viljoen, André John The introduction of a safe, reliable and predictable implant system for dental reconstruction by Professor Per-lngvar Branemark has seen an explosion in the number of patients receiving implant therapy to restore complete and partial edentulism. The reconstruction of partial edentulism may require the linking of the implant to a natural tooth. This study was carried out to investigate the relative mobility of the natural tooth and a Branemark implant, and to determine the feasibility of linking these two elements by means of a fixed prosthesis. The mobility of natural teeth is well documented. However, the mobility and flexibility of a Branemark osseointegrated implant is unknown. Short, medium and long implant abutments were attached to a fixture and placed under load and the deflection of the implant measured. A three-unit bridge linked to a fixture with short, medium and long abutment lengths was also examined. The results indicate that the inherent flexibility of the fixture and abutment system provides the possibility for linkage of the Branemark implant and the natural tooth. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

Cranio-Cervical Inter-Relationships

2026-04-29T00:40:27Z

Cranio-Cervical Inter-Relationships Wallace, Christine J Current concepts of temporomandibular joint (TM joint) disorders and cranio-facial pain vary in philosophy, diagnosis and therapy. Even today, few practitioners agree in their understanding of pain diagnosis and treatment. Thus, many articles (Lindbloom, 1953; Kaye Moran and Pritz, 1975; Gelb, 1979, 1980; Weinberg and Lager, 1980; Carlsson, 1981) have been written on the aetiology, symptomatology and treatment of the functional disturbances of the masticatory system but there is very little information on the specific relationship of cervical and M joint pain. The possibility that functional disturbance of the TM joint might be the cause of certain head and neck symptoms was recognized in the thirties (Costen, 1934) but it was not until the seventies that the high prevalence of symptoms and signs of the TM joint became known (Helkimo, 1979). A study by Alanen and Kirveskari (1982), showed that there was a highly significant overlap between diagnoses of head and neck symptoms by physicians, and TM joint dysfunction by dentists. They showed that TM joint dysfunction is associated not only with headaches but also with many other symptoms in the head and neck area. They suggest that TM joint dysfunction should be suspected when routine medical examination yields no pathological findings, explaining the symptoms in the head and neck area. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Evaluation Of Orthodontic Positioners

2026-04-29T00:36:52Z

Evaluation Of Orthodontic Positioners Vaughan, Peter Powell Tooth positioners are held in high regard by many prominent orthodontists. The literature has many references to the excellent results produced by tooth positioners. For the Begg 'lightwire technique, tooth positioners are considered the best form of retention (Begg 8 Kesling, 1977). However, there has been no clinical evaluation of the tooth positioner in comparison to conventional retainers. The aim of this thesis is to present a method of evaluating post orthodontic treatment occlusal changes in patients who wore either a tooth positioner or a conventional retainer. The conventional retainer used in this study is of the form recommended by Begg and has come to be known in Australia as the “Begg retainer". l have therefore used the term “Begg retainer" in this thesis. Post orthodontic treatment changes were evaluated by assessing the number of inter-occlusal contacts when the jaws where clenched together in maximum intercuspation. I considered that if the Begg retainer and tooth positioner had differing effects, then it would be reflected in assessing the change in the number of occlusal contacts. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Review of dental workforce development and utilisation in Papua New Guinea

2026-04-29T00:06:55Z

Review of dental workforce development and utilisation in Papua New Guinea Vele, Andrew When Papua New Guinea gained political independence from Australia in September 1975 it developed its own internal political system. One of the major political developments that took place was the decentralisation of decision making powers from the Central Government to the provinces which led to the creation of a Provincial Government system. Thus the health functions, including dental, were transferred to the Provincial Governments except for some nationally important health functions which remained with the National Department of Health. The decentralisation of health functions affected the dental services in the provinces, in particular the school dental service. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study.

Exploring Health Professionals' Perceptions and Clinical Manifestations of Chemotherapy and Radiation Therapy-Related Oral and Oropharyngeal Mucositis

2026-04-29T00:36:57Z

Exploring Health Professionals' Perceptions and Clinical Manifestations of Chemotherapy and Radiation Therapy-Related Oral and Oropharyngeal Mucositis Kang, Michelle Background: Oral and oropharyngeal mucositis (OM) refers to inflammation caused by certain chemotherapy (CT) agents and radiation therapy (RT) to mucosal structures. CT-induced OM is usually a manifestation of widespread mucosal inflammation, whereas RT-induced OM only affects irradiated mucosa. Health professionals (HPs) caring for cancer patients may have varying understanding of OM. This may result in variations in assessment, management and patient outcomes. Aims: 1) Determine HPs’ perceptions of oral mucositis, including clinical presentation of CT-induced vs RT-induced oral mucositis, its assessment and management. 2) Document differences in clinical manifestation of CT and RT-induced OM. Methods: 2 studies were undertaken to address each aim respectively: Study 1: HPs involved in the care of head and neck cancer (HNC) patients receiving RT, and haematology patients receiving mucositis-inducing CT regimens were invited to participate in a custom 20-question online survey. Themes included oral mucositis presentation, assessment tools and management. Study 2: Clinical presentation of OM was mapped using a modified Oral Mucositis Assessment Scale (OMAS). Patients undergoing RT for HNC and receiving oral cavity/oropharynx irradiation, as well as haematopoietic stem cell transplantation (HSCT) patients undergoing mucositis-inducing CT were invited to participate. Results: Study 1: The HPs survey had an 81.4% response rate. Most respondents were nurses (33%) and specialist doctors/dentists (25%). The majority identified as part of the Haematology (45%) or Radiation Oncology (32%) services. Most HPs (89% from haematology and 70% from radiation oncology) agreed/strongly agreed that oral mucositis impacted patients’ ability to complete treatment. There was a strong association (p<0.01) between HPs’ specialty and their perceptions of oral mucositis clinical manifestations. Most Radiation Oncology (85%) and all Oral Medicine HPs agreed/strongly agreed that clinical manifestations of CT-induced and RT-induced oral mucositis were different, whereas Haematology HPs varied in their perceptions (11% disagreed, 41% were neutral and 48% agreed/strongly agreed). There was uncertainty regarding differences in management of CT vs RT-induced oral mucositis: 30% of Haematology HPs and 45% Radiation Oncology HPs agreed/strongly agreed but most (52% and 45% respectively in each group) responded “neutral”. Study 2: Although there was an increase in OMAS scores during treatment and decreasing back to baseline over time in both groups, the time course in which these changes occurred were different. There was a shorter duration for the CT group compared to the RT group. The maximum mucositis coverage score was higher in the RT group (5.50) compared to the CT group (3.06). All the highest OMAS scores occurred between days 10-12 post stem cell infusion for the CT group, and occurred at week 6 and week 8 for the RT group. OM developed predominantly on the non-keratinised mucosa for the CT group, whereas a greater portion of RT participants developed OM on keratinised mucosa (10% CT participants and 44% RT participants developed OM on keratinised mucosa). Conclusions: Study 1: OM was recognised by HPs to adversely impact HSCT and HNC RT patients’ ability to complete treatment. There were differences in HPs’ perceived understanding of OM manifestations and management. Interventions to address these may reduce unwanted variations in patient care and outcomes, such as when HPs rotate between services or provide inter-disciplinary care. Study 2: Differences in clinical presentation of OM were observed between RT and CT groups including duration of OM, as well as OM location. Further data analysis may improve understanding of OM relating to its aetiopathogenesis, allow development of different management strategies between the RT and CT groups and ultimately optimise cancer treatment outcomes for patients.

Guidelines for innovation in dental education during the coronavirus disease 2019 pandemic

2026-04-29T00:40:30Z

Guidelines for innovation in dental education during the coronavirus disease 2019 pandemic Hong, G.; Chang, T.Y.; Terry, A.; Chuenjitwongsa, S.; Park, Y.S.; Tsoi, J.K.; Kusdhany, M.F.L.S.; Egusa, H.; Yamada, S.; Kwon, J.S.; Seow, L.L.; Garcia, M.C.A.G.; Wong, M.L.; Auychai, P.; Hsu, M.-L. During the current coronavirus disease 2019 (COVID-19) pandemic, dental education and training requiring face-to-face interaction must prioritize infection prevention and the safety of students, staff, and patients. In July 2020, the Association for Denta

Errors of interpretation of dental radiographs among dental professionals: A survey

2020-12-14T06:57:31Z

Errors of interpretation of dental radiographs among dental professionals: A survey Shwethah, Hegde Radiographic interpretations constitute an essential component of information available to dentists when they are formulating a diagnosis. However, interpretation of images is a human endeavour and is subject to the limitations of our ability. Making a correct diagnosis relies on visual detection, pattern recognition, working memory functions and also cognitive reasoning to perceive the meaning of the interpretation. Mistakes may occur in both the visual perception and the cognitive interpretation of images, and this may have serious consequences for the patient. In medical radiology literature, this issue has been recognised for many years, and numerous publications have reported interpretive errors on chest radiographs and mammograms. The rate of interpretation error is in the range of 2-20% and varies depending on the type of radiological investigation. In dentistry, the rate of error of interpretation of dental radiographs is not as well documented. Clinical settings are often hectic with information ambiguous or incomplete, and the dentist is often under pressure to make diagnostic assessments quickly. As radiographic interpretation is reliant on visual perception, errors in interpretation can occur under such constrained conditions. The subjective nature of the interpretation also makes it difficult to establish what is an ‘error’ as opposed to an acceptable variation in opinion. This study explores the occurrence and causes of errors of interpretation of dental radiographs among dental practitioners using an online anonymised questionnaire. With this survey, we aim to evaluate the perceptions of errors, definitions of errors, their contributing factors and strategies to reduce errors. This research will create a benchmark on the incidence and prevalence of errors of interpretation in dentistry and the will be used to improve the diagnostic accuracy of machine learning algorithms.

Variation in Memory T Cells Following Periodontal Treatment

2020-12-09T02:09:43Z

Variation in Memory T Cells Following Periodontal Treatment Medara, Nidhi T cells are a major cell subset of the adaptive immune system that play a central role in periodontitis. One distinguishing feature of adaptive immunity is immunological memory. Memory refers to the ability of the immune system to respond more rapidly and efficiently to a specific pathogen that has been encountered previously. Memory T cells can be divided into four subsets based on surface expression of CD45RA and CCR7 expression where TN cells are CCR7+CD45RA+, effector memory T cells which re-express CD45RA (TEMRA) are CCR7-CD45RA+, central memory T cells (TCM) are CCR7+CD45RA-, effector memory T cells (TEM) are CCR7-CD45RA-. Periodontal parameters and peripheral blood mononuclear cells were collected from 54 periodontitis patients at baseline, 3-, 6- and 12-months post-therapy and 40 healthy controls. TN, TCM, TEM and TEMRA cells were identified using flow cytometry in CD4+, CD8+, CD4+CD8+ and CD4-CD8- T-cells At baseline, periodontitis subjects had significantly lower TN but higher CD4+ TCM, CD8+ TCM, CD4+CD8+ TEM, and CD4-CD8- TEM cell proportions compared to health. Periodontal therapy decreased TEM and CD4+ and CD8+ TCM cells, but increased TN and CD4+ and CD8+ TEMRA cells. Thus, periodontal management modifies peripheral memory T-cell profile in periodontitis.

Myeloperoxidase and Inflammatory Bowel Disease

2020-09-22T22:37:03Z

Myeloperoxidase and Inflammatory Bowel Disease Chami, Belal Examining the relationship of neutrophil extracellular traps (NETs) in clinical IBD samples and the role of myeloperoxidase in modulating the gut microbiome.

Money Where Your Mouth Is: Dentistry and Commercialism

2020-09-10T00:44:58Z

Money Where Your Mouth Is: Dentistry and Commercialism Holden, Alexander In this presentation, the audience will be taken on a journey through my current research which explores the nature of the relationship between professional and commercial obligations in dentistry. Using qualitative methods, my work draws out the key themes that demonstrate how the commercial environment of dental practice impacts attitudes towards patients as well as perspectives relating to commercial behaviours such as advertising and competition.

Data files of work described in the manuscript: Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping

2026-04-29T00:40:26Z

Data files of work described in the manuscript: Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping Zoellner, Hans; Chami, Belal; Kelly, Elizabeth; Moore, Malcolm A.S. These are data files for work described in the manuscript: Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping. At the time these files were uploaded to the University of Sydney Research Repository, this work was in-press in the open-access on-line journal PLoS One. A pre-print of the manuscript was also available at: bioRxiv doi: http://biorxiv.org/cgi/content/short/770693v1. FACS, proliferation and migration data are provided in two separate MS Excel files titled: 1) Migration Data: which contains calculations for distance migrated in scratch assays; 2) FACS Proliferation and Scatterplots: which contains data for FACS forward and side scatter analysis, as well as proliferation assays and scatterplots for all data. MS Excel data files and explanatory notes

The extend of orthodontically induced inflammatory root resoption following transverse and vertical jiggling movement with heavy forces for 12 weeks: A micro-CT study

2026-03-26T01:08:34Z

The extend of orthodontically induced inflammatory root resoption following transverse and vertical jiggling movement with heavy forces for 12 weeks: A micro-CT study Ng, Carolyn Lian Tat This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

CYTOKINES IN GINGIVAL CREVICULAR FLUID AND ROOT RESORPTION: A MICROCOMPUTED TOMOGRAPHY STUDY

2026-03-26T01:18:02Z

CYTOKINES IN GINGIVAL CREVICULAR FLUID AND ROOT RESORPTION: A MICROCOMPUTED TOMOGRAPHY STUDY Chiu, Jenkin J This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

The effect of azithromycin on the non-surgical treatment of peri-implantitis. A prospective double blind placebo controlled randomised clinical trial. A pilot study

2026-03-26T01:08:30Z

The effect of azithromycin on the non-surgical treatment of peri-implantitis. A prospective double blind placebo controlled randomised clinical trial. A pilot study Kalos, Alex Peter 3.0 Abstract 3.1 Aim The aim of this study is to determine in a randomized control trial the microbiological and immunological effect of azithromycin (AZM) in cases of peri-implantitis versus a placebo at the peri-implant tissue level in a sample of patients diagnosed with peri-implantitis. 3.2 Methodology 17 patients referred to periodontics department at the Westmead Centre for Oral Health for the treatment of peri-implantitis were invited to participate in the study. Five subjects with healthy implants were also recruited for the immuno-regulatory part of the study to act as healthy controls. After clinical assessment, subjects received non-surgical debridement of implant/abutment surfaces and oral hygiene instruction. The subjects were then randomly assigned to receive AZM (1 x 500mg capsule per day for 3 days) and the controls received placebo tablets. Submucosal plaque and peri-implant crevicular fluid samples were collected from selected implants at the following time points: day 0, 3, 7, 21, 90 and 180 for microbiological and immunological analysis. The primary outcome variables were mean counts and mean changes from baseline levels in the anaerobic and aerobic microbiological counts (CFU/ml) and the proinflammatory cytokine Il-1β levels (pg/ml) over time. Analysis of the species associated with peri-implantitis and the cytokine levels of healthy control implants was also determined. 7 3.3 Results The placebo group showed a trend for aerobic bacteria to steadily rebound after day 7. This rebound appeared to be delayed until day 90 in the azithromycin group. Both treatment groups showed a trend for the mean anaerobic bacteria count to decrease from day 1 to 7 after which a gradual increase in counts was observed for the remainder of the study. The magnitude of this rebound in anaerobic bacteria levels was greater in the placebo group. There were no statistical significant differences observed between the two groups at any times points (p>0.05). The placebo group showed a mean change from baseline resulting in reduction in anaerobic bacteria counts up to day 7, after which a rebound in bacteria levels were observed above baseline levels and sustained throughout the remainder of the study. The azithromycin group showed mean changes from baseline levels resulting in a sustained decrease in mean anaerobic bacteria levels below baseline observed up 180 days. No statistical significant differences observed between the two groups at any times points (p>0.05). Orange complex species were found in the highest frequency (94.1%) whilst the red complex bacteria were found at the lowest frequency (17.6%) with no statistical significant differences between treatment groups observed at baseline. Both groups demonstrated a trend for mean reduction in IL-1β levels after treatment over time which was sustained throughout the study. The magnitude of changes from baseline levels appeared greater in the azithromycin group. No statistical significance was observed between treatment groups (p>0.05). It was observed that the percentage frequency of subjects who were “positive responders” was higher in the azithromycin group at all time points. 8 3.4 Conclusion The reductions and subsequent recolonization observed in the immunological data closely correlated with that of the microbiological data. Despite reductions in levels of IL-1β initially after treatment, the levels gradually rebounded throughout the course of the study. Throughout all time points, IL-1β did not return to baseline levels, which were likely a result of the treatment effect. Similarly, a reduction in microbiological parameters was seen initially post therapy with a trend for a gradual rebound in counts seen over time. No statistical significant effect was observed between treatment groups despite a trend for a greater magnitude change in outcome measures for subjects’ allocated azithromycin. We demonstrated that the response to non-surgical treatment, with or without adjunctive azithromycin is highly variable and unpredictable with gradual rebound in immunological and microbiological parameters seen after 6 months. Because of the limited number of patients recruited, no definitive conclusions can be made. There is clear indication that further longitudinal research into the effects of azithromycin at peri-implant-host interface is warranted. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

The long term stability of soft and hard tissues surrounding Branemark Dental Implants

2026-03-26T01:08:32Z

The long term stability of soft and hard tissues surrounding Branemark Dental Implants Nguyen, Khai Quang This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Prediction of the efficacy of a mandibular advancement splint in the treatment of obstructive sleep apnea using various diagnostic methods

2026-03-26T01:08:32Z

Prediction of the efficacy of a mandibular advancement splint in the treatment of obstructive sleep apnea using various diagnostic methods Blignaut, Anel This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

A COMPARATIVE HISTOMORPHOLOGICAL AND MICRO CT STUDY OF THE PRIMARY STABILITY AND THE OSSEOINTEGRATION OF THE SYDNEY MINI-SCREW: AN ANIMAL STUDY USING NEW ZEALAND RABBITS

2026-03-26T01:08:27Z

A COMPARATIVE HISTOMORPHOLOGICAL AND MICRO CT STUDY OF THE PRIMARY STABILITY AND THE OSSEOINTEGRATION OF THE SYDNEY MINI-SCREW: AN ANIMAL STUDY USING NEW ZEALAND RABBITS Bacopulos Marangu, Anastacia Introduction: Failure rate of orthodontic miniscrews (MSs) is 7-50%. To address this problem and to promote primary stability of the miniscrew (MS), we recently designed and developed The Sydney Mini Screw (SMS, Patent number: PCT2009014) which can be used with injectable bone graft substitutes (iBGS). The aim of this study was to assess in vivo dispersion of bone graft substitutes (BGS) and the integration of the SMS to the cortical and trabecular bone using New Zealand femur and tibia rabbit model. Method: Twenty-four MSs were randomly placed in each proximal tibia and femur of 6 New Zealand rabbits with an open surgery process. Aarhus MS was used as a control and the effect of injection of BGS was studied by implanting SMS with and without BGS injection. The dispersion and integration of the MS were studied by using micro CT (μCT) and histochemical analysis at two time points, 0 day and 8 weeks post-implantation. Results: BGS were successfully injected to the SMS and thereafter hardened in situ to fill the bone void. After 8 weeks, μCT results revealed that the iBGS were resorbed and bone tissue was formed around the MS and within its lateral exit holes. The osteointegration of the SMS samples showed similar histologic characteristics to that of Arhus controls, and initial drilling for injection of bone cements into SMS did not seem to affect adjacent bone quality. Conclusion: Results of this pilot animal study showed the high potential of SMS and the developed technique to promote the primary stability of MS. Keywords: Primary stability; orthodontic miniscrew; injectable bone graft substitute. This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Treatment of Class III malocclusions using temporary anchorage devices (TADs) the Alt RAMEC protocol and inermaxillary Class III elastics in the growing patient

2026-03-26T01:18:03Z

Treatment of Class III malocclusions using temporary anchorage devices (TADs) the Alt RAMEC protocol and inermaxillary Class III elastics in the growing patient Al-Mozany, Saad

The extent of root resorption following the application of ascending and descending magnetic forces A micro CT study

2026-03-26T01:18:04Z

The extent of root resorption following the application of ascending and descending magnetic forces A micro CT study Huang, Tiffany

The effect of mechanical vibration (Acceledent 30Hz) applied to the hemimaxilla on root resporption and tooth movement after application of orthodontic force. A micro CT study

2026-03-26T01:18:02Z

The effect of mechanical vibration (Acceledent 30Hz) applied to the hemimaxilla on root resporption and tooth movement after application of orthodontic force. A micro CT study Tan, Daniel

The Sydney intrusion spring SIS An appliance for the intrusion of posterior maxillary teeth A prospective clinical study

2026-03-26T01:18:02Z

The Sydney intrusion spring SIS An appliance for the intrusion of posterior maxillary teeth A prospective clinical study Foot, Riaan

The Effect Of Mechanical Vibration (113 Hz Applied to Maxillary First Premolars) On Root Resorption Associated With Orthodontic Force: A Micro-CT Study.

2026-04-29T00:40:27Z

The Effect Of Mechanical Vibration (113 Hz Applied to Maxillary First Premolars) On Root Resorption Associated With Orthodontic Force: A Micro-CT Study. Grove, Jonathan